Antimycobacterial activity of Indigofera suffruticosa with activation potential of the innate immune system

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:23:53Z
dc.date.available2014-05-20T13:23:53Z
dc.date.created2014-05-20T13:23:53Z
dc.date.issued2010-08-01
dc.identifierPharmaceutical Biology. Philadelphia: Taylor & Francis Inc, v. 48, n. 8, p. 878-882, 2010.
dc.identifier1388-0209
dc.identifierhttp://hdl.handle.net/11449/7285
dc.identifier10.3109/13880200903303471
dc.identifierWOS:000281304800006
dc.identifier0000-0003-3032-2556
dc.description.abstractMycobacterium tuberculosis is responsible for over 8 million cases of tuberculosis (TB) annually. Natural products may play important roles in the chemotherapy of TB. The antimycobacterial activity and the innate immune response of methanol (METH) and dichloromethane (DCM) extracts of Indigofera suffruticosa Miller (Fabaceae) were evaluated. We observed that the minimum inhibitory concentrations (MICs) for METH and DCM extracts were 125 and 1000 mu g/mL, respectively. However, they were able to induce the innate immune response through the production of high levels of NO and TNF-alpha (p < 0.001) by peritoneal exudate cells (PECs). These results suggest that I. suffruticosa extracts may have an important immunological role in the control of TB once macrophage activity is induced by them.
dc.languageeng
dc.publisherTaylor & Francis Inc
dc.relationPharmaceutical Biology
dc.relation1.918
dc.relation0,563
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAntimycobacterial activity
dc.subjectIndigofera suffruticosa
dc.subjectinnate immune response
dc.titleAntimycobacterial activity of Indigofera suffruticosa with activation potential of the innate immune system
dc.typeArtículos de revistas


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