Efficacy in treatment of subclinical cervical HPV infection without intraepithelial neoplasia: systematic review

dc.creatorRussomano, Fábio Bastos
dc.creatorReis, Aldo
dc.creatorCamargo, Maria José de
dc.creatorDutra, Maria Virgínia Peixoto
dc.creatorFonseca, Sandra Costa
dc.creatorAnderson, Jean
dc.date.accessioned2010-08-23T16:00:23Z
dc.date.available2010-08-23T16:00:23Z
dc.date.created2010-08-23T16:00:23Z
dc.date.issued2000
dc.identifierRUSSOMANO, Fábio et al. Efficacy in treatment of subclinical cervical HPV infection without intraepithelial neoplasia: systematic review. São Paulo Med. J., São Paulo, v. 118, n. 4, p. 109-115, jul. 2000.
dc.identifier1516-3180
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/296
dc.identifier10.1590/S1516-31802000000400007
dc.description.abstractCONTEXTO: O tratamento da infecção subclínica pelo papilomavírus humano (HPV) no colo uterino é controverso. OBJETIVO: Avaliar a eficácia de alguma terapia para infecção pelo HPV no colo uterino sem neoplasia intraepitelial. MÉTODO: Realizamos uma revisão sistemática com uma busca abrangente de estudos no Medline, LILACS, Excerpta medica, AIDSLINE, Popline, Cochrane Library e listas de referências de outros autores para identificar estudos experimentais sobre terapia para a infecção subclínica pelo HPV sem neoplasia intraepitelial no colo uterino. Para identificar artigos não publicados, também contactamos especialistas da área, registros de ensaios clínicos, indústrias farmacêuticas, instituições governamentais e de fomento à pesquisa. Também procuramos por estudos através da Internet e em livros de abstracts de alguns eventos médicos. Os estudos identificados foram mascarados e selecionados por critérios de inclusão que auxiliaram a garantir sua validade interna. Os dados sobre regressão ou progressão da infecção pelo HPV foram extraídos dos estudos incluídos. RESULTADOS: Identificamos 67 estudos relacionados ao tratamento da infecção subclínica pelo HPV sem neoplasia intraepitelial do colo uterino (NIC). Apenas cinco ensaios clínicos atenderam aos critérios de inclusão e nenhum demonstrou diferenças significativas entre o grupo em teste e o grupo-controle no que se refere a regressão da infecção pelo HPV (com ou sem NIC I) ou progressão para graus mais altos de NIC. CONCLUSÃO: As evidências de eficácia de alguma terapia para infecção subclínica pelo HPV sem neoplasia intraepitelial no colo uterino encontradas na literatura médica foram insatisfatórias.
dc.languageeng
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dc.rightsrestricted access
dc.subjectHPV
dc.subjectNeoplasia Intraepitelial Cervical
dc.subjectTratamento
dc.subjectRevisão sistemática
dc.titleEfficacy in treatment of subclinical cervical HPV infection without intraepithelial neoplasia: systematic review
dc.typeArticle


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