dc.creatorCalvete Chornet, Juan José
dc.creatorSanz, Libia
dc.creatorAngulo Ugalde, Yamileth
dc.creatorLomonte, Bruno
dc.creatorGutiérrez, José María
dc.date.accessioned2018-03-12T20:04:27Z
dc.date.accessioned2019-04-25T15:38:18Z
dc.date.available2018-03-12T20:04:27Z
dc.date.available2019-04-25T15:38:18Z
dc.date.created2018-03-12T20:04:27Z
dc.date.issued2009
dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0014579309002142
dc.identifier0014-5793
dc.identifierhttp://hdl.handle.net/10669/74295
dc.identifier10.1016/j.febslet.2009.03.029
dc.identifier741-A8-521
dc.identifier19303875
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/2386167
dc.description.abstractVenoms comprise mixtures of peptides and proteins tailored by Natural Selection to act on vital systems of the prey or victim. Here we review our proteomic protocols for uncoiling the composition, immunological profile, and evolution of snake venoms. Our long-term goal is to gain a deep insight of all viperid venom proteomes. Knowledge of the inter- and intraspecies ontogenetic, individual, and geographic venom variability has applied importance for the design of immunization protocols aimed at producing more effective polyspecific antivenoms. A practical consequence of assessing the cross-reactivity of heterologous antivenoms is the possibility of circumventing the restricted availability of species-specific antivenoms in some regions. Further, the high degree of target specificity makes toxins valuable scaffolds for drug development.
dc.languageen_US
dc.sourceFEBS Letters, vol. 583, 1736-1743
dc.subjectSnake venom
dc.subjectSnake venomics
dc.subjectAntivenomics
dc.titleVenom, venomics, antivenomics
dc.typeArtículos de revistas
dc.typeArtículo científico


Este ítem pertenece a la siguiente institución