dc.creator | Corrales Aguilar, Eugenia | |
dc.creator | Hoffmann, Katja | |
dc.creator | Hengel, Hartmut | |
dc.date.accessioned | 2019-02-27T20:56:25Z | |
dc.date.accessioned | 2019-04-25T15:37:17Z | |
dc.date.available | 2019-02-27T20:56:25Z | |
dc.date.available | 2019-04-25T15:37:17Z | |
dc.date.created | 2019-02-27T20:56:25Z | |
dc.date.issued | 2014-10-07 | |
dc.identifier | https://link.springer.com/article/10.1007/s00281-014-0448-2 | |
dc.identifier | 1863-2300 | |
dc.identifier | http://hdl.handle.net/10669/76626 | |
dc.identifier | 10.1007/s00281-014-0448-2 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/2385937 | |
dc.description.abstract | The constant region of IgG antibodies mediates antiviral activities upon engaging host Fcγ receptors (FcγRs) expressed by a variety of immune cells, such as antibody-dependent cellullar cytotoxcity (ADCC) executed by natural killer (NK)cells. Human cytomegalovirus (HCMV) is unique among viruses by encoding also an array of several Fcγ-binding glycoproteins with cell surface disposition and concomitant incorporation into the virion. Evidence is increasing that the virus-encoded Fcγ receptors differ in their Fcγ binding mode but effectively operate as adversaries of host FcγRs since they are able to prevent IgG-mediated triggering of activating host FcγRs, i.e., FcγRI, FcγRIIA, and FcγRIIIA. Here we discuss virus-encoded FcγRs as the first known HCMV inhibitors of IgG-mediated immunity which could account for the limited efficacy of HCMV hyperimmune globulin in clinical settings. A better understanding of their molecular mode of action opens up new perspectives for improving IgG therapies against HCMV disease. | |
dc.language | en_US | |
dc.relation | | |
dc.source | Seminars in Immunopathology, vol. 36(6), pp. 627–640 | |
dc.subject | FcγRs | |
dc.subject | Immune evasion | |
dc.subject | Cytomegalovirus | |
dc.subject | IgG | |
dc.subject | ADCC | |
dc.title | CMV-encoded Fcγ receptors: modulators at the interface of innate and adaptive immunity | |
dc.type | Artículos de revistas | |