Costa Rica | Artículos de revistas
dc.creatorGené, José Antonio
dc.creatorRoy Sund, Astrid
dc.creatorRojas Céspedes, Gustavo
dc.creatorGutiérrez, José María
dc.creatorCerdas Fallas, Luis
dc.date.accessioned2016-11-07T17:28:31Z
dc.date.accessioned2019-04-25T15:13:18Z
dc.date.available2016-11-07T17:28:31Z
dc.date.available2019-04-25T15:13:18Z
dc.date.created2016-11-07T17:28:31Z
dc.date.issued1989
dc.identifierhttp://www.sciencedirect.com/science/article/pii/0041010189900962
dc.identifier0041-0101
dc.identifierhttp://hdl.handle.net/10669/29156
dc.identifier10.1016/0041-0101(89)90096-2
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/2380555
dc.description.abstractThe coagulant, defibrinating, fibrino lytic and fibrinogenolytic activities of venoms from ten species of Costa Rican crotaline snakes were studied, together with the neutralization of these effects by a polyvalent antivenom. The venoms of Bothrops asper, B. schlegelii, B. nummifer, B. godmani, Lachesis muta and Crotalus durissus induced a coagulant effect in vitro, and all of them, with the exception of B. nummifer, also induced defibrination in vivo. The four non-coagulant venoms (B. lateralis, B. ophryomegas, B. nasuta and B. picadoi) induced a degradation of the alpha (A) chain of fibrinogen, thereby inhibiting coagulation. However, they did not induce defibrination upon i.v. injection. All of the venoms showed fibrinolytic activity in vitro. Polyvalent antivenom was effective in the neutralization of coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of these venoms, with the exception of coagulant effect induced by C. durissus venom. Since only three venoms are used in the immunization of horses, these results demonstrate the high degree of immunological cross reactivity between components affecting coagulation in Costa Rican crotaline snake venoms.
dc.languageen_US
dc.sourceToxicon Volumen 27, Número 8, 1989
dc.subjectAnimals
dc.subjectAntivenins
dc.subjectCoagulants
dc.subjectCosta Rica
dc.subjectCrotalid Venoms
dc.subjectFibrinogen
dc.subjectFibrinolytic Agents
dc.subjectHumans
dc.subjectIn Vitro Techniques
dc.subjectMice
dc.subjectSheep
dc.subjectSnake venom
dc.titleComparative study on coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenom
dc.typeArtículos de revistas
dc.typeArtículo científico


Este ítem pertenece a la siguiente institución