Antiproliferative and antiestrogenic activities of bonediol an alkyl catechol from bonellia macrocarpa

dc.contributorEDGAR EMMANUEL CAAMAL FUENTES
dc.contributorSERGIO RUBEN PERAZA SANCHEZ
dc.creatorROSA ESTHER MOO PUC
dc.date2015
dc.date.accessioned2018-11-19T14:14:43Z
dc.date.available2018-11-19T14:14:43Z
dc.identifierhttp://cicy.repositorioinstitucional.mx/jspui/handle/1003/501
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/2256410
dc.descriptionThe purpose of this study was to investigate antiproliferative activity of bonediol, an alkyl catechol isolated from the Mayan medicinal plant Bonellia macrocarpa. Bonediol was assessed for growth inhibition of androgen-sensitive (LNCaP), androgen-insensitive (PC-3), and metastatic androgen-insensitive (PC-3M) human prostate tumor cells; toxicity on normal cell line (HEK 293) was also evaluated. Hedgehog pathway was evaluated and competitive 3H-estradiol ligand binding assay was performed. Additionally, antioxidant activity on Nrf2-ARE pathway was evaluated. Bonediol induced a growth inhibition on prostate cancer cell lines (IC50 from 8.5 to 20.6 μM). Interestingly, bonediol binds to both estrogen receptors (ERα (2.5 μM) and ERβ (2.1 μM)) and displaces the native ligand E2 (17β-estradiol). No significant activity was found in the Hedgehog pathway. Additionally, activity of bonediol on Nrf2-ARE pathway suggested that bonediol could induce oxidative stress and activation of detoxification enzymes at 1 μM (3.8-fold). We propose that the compound bonediol may serve as a potential chemopreventive treatment with therapeutic potential against prostate cancer.
dc.formatapplication/pdf
dc.languageeng
dc.relationinfo:eu-repo/semantics/dataset/DOI/DOI: 10.1155/2015/847457
dc.relationcitation:Moo-Puc, R., Caamal-Fuentes, E., Peraza-Sánchez, S. R., Slusarz, A., Jackson, G., Drenkhahn, S. K., & Lubahn, D. B. (2015). Antiproliferative and antiestrogenic activities of bonediol an alkyl catechol from bonellia macrocarpa. BioMed Research International, 2015 doi:10.1155/2015/847457
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceBioMed Research International. Article ID 847457, (1-6), 2015
dc.subjectinfo:eu-repo/classification/Autores/ANTIESTROGEN
dc.subjectinfo:eu-repo/classification/Autores/ANTINEOPLASTIC AGENT
dc.subjectinfo:eu-repo/classification/Autores/BONEDIOL
dc.subjectinfo:eu-repo/classification/Autores/CATECHOL
dc.subjectinfo:eu-repo/classification/Autores/CYCLOPAMINE
dc.subjectinfo:eu-repo/classification/cti/2
dc.titleAntiproliferative and antiestrogenic activities of bonediol an alkyl catechol from bonellia macrocarpa
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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