The castor bean consists of approximately 50% oil is a promising candidate for biodiesel and bio lubricant production. Along this process, there is a byproduct called castor cake that is currently used in fertilizers (1). Although these castor cakes are rich in protein and fiber, the presence of toxic compounds limits their use as an animal feed. Biological detoxification, using solid-state fermentation (SSF) with filamentous fungi, has been used to detoxify other residues, showing good results (2). In addition to promoting residue-detoxification, SSF of castor bean waste represents an interesting and low-cost alternative for generating useful enzymes (3) and its residual oil can be used to produce lipases (4) that have found a great number of biotechnological they are able to catalyze and being considered as the most versatile biocatalyst (5). The objective of this work was the detoxification of castor bean cake and the lipase production by using four filamentous fungi under SSF conditions.