| dc.creator | Toro de Méndez, Morelva | |
| dc.creator | Llombart-Bosch, Antonio | |
| dc.date | 2013-05-14T17:43:49Z | |
| dc.date | 2013-05-14T17:43:49Z | |
| dc.date | 2009 | |
| dc.date.accessioned | 2017-03-03T14:38:20Z | |
| dc.date.available | 2017-03-03T14:38:20Z | |
| dc.identifier | http://www.saber.ula.ve/handle/123456789/37052 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/219490 | |
| dc.description | Artículo publicado en: Virchows Arch (2009) 455:235–243. DOI 10.1007/s00428-009-0818-7 | |
| dc.description | Ubiquitin and telomerase immunohistochemical
expression patterns in cervical cancer were compared with
normal cervical tissue samples. Eighty-one cervical cancer
cases and 22 normal exo–endocervical tissue were examined
with polyclonal antibody for ubiquitin and 44G12 clone for
telomerase using tissue microarrays. The results were interpreted
using a semiquantitative scale The average age of
patients was 50.67 years. The most frequent histological types
were moderately differentiated epidermoid carcinoma (43.5%),
according to the degree of differentiation, and endocervical
adenocarcinoma (42.1%). Immunohistochemical findings were
as follows: 98.7% of cervical cancers showed immunoexpression
for ubiquitin and 52.6% for telomerase. Statistically
significant differences were found in tumor immunoreactivity
when compared with control tissue (p<0.0007) for both
biomarkers. There was no significant difference in biomarker
expression at different histological types of tumors, although
telomerase was less expressed in endocervical adenocarcinoma.
Our findings confirmthat abnormal immunoexpression
pattern of ubiquitin and telomerase is common in HPVpositive
cervical cancer, indicating the existence of an intense
degradation of proteins, subsequent cellular immortalization
and maintenance of the malignant phenotype. | |
| dc.description | 235-243 | |
| dc.description | tmorelva@ula.ve | |
| dc.description | antonio.llombart@uv.es | |
| dc.language | en | |
| dc.publisher | Venezuela | |
| dc.subject | Facultad de Farmacia y Bioanálisis | |
| dc.subject | Cervical cancer | |
| dc.subject | Immunohistochemical expression | |
| dc.subject | Telomerase | |
| dc.subject | Ubiquitin | |
| dc.subject | Biología | |
| dc.subject | Artículos | |
| dc.title | Immunohistochemical expression of ubiquitin and telomerase in cervical cancer. | |
| dc.type | Artículos de revistas | |
