| dc.contributor | CAPES | en-US |
| dc.creator | Leopoldino, Maria Aparecida Andreza | |
| dc.creator | Chaves, Eunice Beatriz Martin | |
| dc.creator | da Silva, Carmem Lúcia Oliveira | |
| dc.creator | Corleta, Helena von Eye | |
| dc.date | 2017-12-15 | |
| dc.date.accessioned | 2018-11-07T18:54:53Z | |
| dc.date.available | 2018-11-07T18:54:53Z | |
| dc.identifier | https://seer.ufrgs.br/hcpa/article/view/73975 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/2174880 | |
| dc.description | Objective: To evaluate factors that may interfere in mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV).Method: A historical cohort study with a sample of 299 HIV-infected mothers and their newborns who delivered at the Obstetric Center of the Hospital de Clínicas de Porto Alegre, southern Brazil, from January 2010 to December 2014.Results: Of the 299 newborns of HIV-infected mothers, 3.7% (n = 11) were infected. Of those, 90.9% (n = 10) were born by cesarean section; 90.9% (n = 10) had ≥ 37 weeks; 54.6% (n = 6) received zidovudine starting within the first 4 hours after birth; and 45.4% (n = 5) received zidovudine and nevirapine. Four women whose newborns were infected with HIV had syphilis during pregnancy (36.4%). Poor adherence to highly active antiretroviral therapy (HAART) (p < 0.003), viral load ≥ 1000 copies/mL or ignored in the third trimester (p < 0.000), and CD4 count < 500 cells/mm3 in the third trimester (p < 0.046) were significantly associated with an increased risk of MTCT.Conclusion: Lack of control of risk factors may contribute to unfavorable rates of MTCT of HIV.Keywords: Risk factors; infectious disease transmission; vertical transmission; acquired immunodeficiency syndrome | en-US |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | HCPA/FAMED/UFRGS | en-US |
| dc.relation | https://seer.ufrgs.br/hcpa/article/view/73975/pdf | |
| dc.rights | Direitos autorais 2017 Clinical and Biomedical Research | pt-BR |
| dc.rights | http://creativecommons.org/licenses/by/4.0 | pt-BR |
| dc.source | Clinical & Biomedical Research; v. 37, n. 4 (2017) | en-US |
| dc.source | Clinical and Biomedical Research; v. 37, n. 4 (2017) | pt-BR |
| dc.source | 2357-9730 | |
| dc.source | 0101-5575 | |
| dc.subject | Obstetrics and Pediatrics | en-US |
| dc.subject | Risk factors; infectious disease transmission; vertical transmission; acquired immunodeficiency syndrome | en-US |
| dc.subject | Infectious diseases | en-US |
| dc.title | Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil | en-US |
| dc.type | Artículos de revistas | |
| dc.type | Artículos de revistas | |
| dc.type | Avaliado por Pares | pt-BR |
| dc.type | Peer-reviewed Article | en-US |
