In vitro effect of N-acetyl-L-cysteine on glutathione and sulfhydryl levels in X-linked adrenoleukodystrophy patients

dc.creatorMarchetti, Desirèe Padilha
dc.creatorDonida, Bruna
dc.creatorDeon, Marion
dc.creatorJacques, Carlos Eduardo
dc.creatorJardim, Laura Bannach
dc.creatorVargas, Carmen Regla
dc.date2017-04-20
dc.identifierhttps://seer.ufrgs.br/index.php/hcpa/article/view/69868
dc.descriptionIntroduction: Recent evidence shows that oxidative stress seems to be related with the pathophysiology of X-linked adrenoleukodystrophy (X-ALD), a neurodegenerative disorder. Methods: In the present study, the in vitro effect of N-acetyl-L-cysteine (NAC) on glutathione (GSH) and sulfhydryl levels in X-ALD patients was evaluated. Results: A significant reduction of GSH and sulfhydryl content was observed in X-ALD patients compared to the control group. Furthermore, 5 mM of NAC, in vitro, led to an increase in GSH content and sulfhydryl groups in these patients. Conclusion: These data probably indicate that an adjuvant therapy with the antioxidant NAC could improve the oxidative imbalance in X-ALD patients.Keywords: X- linked adrenoleukodystrophy; N-acetyl-L-cysteine; glutathione; sulfhydrylen-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherHCPA/FAMED/UFRGSpt-BR
dc.relationhttps://seer.ufrgs.br/index.php/hcpa/article/view/69868/pdf
dc.rightsCopyright (c) 2017 Clinical and Biomedical Researchpt-BR
dc.sourceClinical & Biomedical Research; Vol. 37 No. 1 (2017)en-US
dc.sourceClinical and Biomedical Research; v. 37 n. 1 (2017)pt-BR
dc.source2357-9730
dc.subjectX- linked adrenoleukodystrophyen-US
dc.subjectN-acetyl-L-cysteineen-US
dc.subjectglutathioneen-US
dc.subjectsulfhydrylen-US
dc.titleIn vitro effect of N-acetyl-L-cysteine on glutathione and sulfhydryl levels in X-linked adrenoleukodystrophy patientsen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typePeer-reviewed Articleen-US
dc.typeAvaliado por Parespt-BR


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