Caffeine teratogenicity in rats: morphological characterization and hypothesized mechanisms

dc.contributorHCPAen-US
dc.contributorCNPQen-US
dc.contributorCAPESen-US
dc.contributorFAPERGSen-US
dc.creatorSouza, Ana Claudia
dc.creatorDussán-Sarria, Jairo Alberto
dc.creatorSouza, Andressa
dc.creatorCaumo, Wolnei
dc.creatorTorres, Iraci Lucena da Silva
dc.date2017-01-17
dc.date.accessioned2018-11-07T18:54:36Z
dc.date.available2018-11-07T18:54:36Z
dc.identifierhttps://seer.ufrgs.br/hcpa/article/view/68287
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/2174822
dc.descriptionCaffeine consumption during pregnancy has been shown in the scientific literature to be associated with teratogenicity such as low birth weight, fetal malformations, and miscarriage. However, the morphological alterations of the offspring of dams exposed during pregnancy have not been consistently described, and the mechanisms why they occur remain elusive. Thus, we aimed to characterize the offspring malformations induced by moderate and high doses of caffeine during pregnancy. Dams were divided into three groups: control, moderate (0.3 g/L), and high dose (1.0 g/L) of caffeine, which was provided in the drinking water beginning on gestational day 1 and continuing throughout the entire gestation. At moderate doses, only one of the dams had stillborn pups, although no macroscopic malformations were observed. High doses of caffeine induced significantly more malformations (P<0.001) and early death (before P4). The malformations observed were related to fetal development and cardiovascular alterations, namely bruises, macrocephaly with short limbs, abnormal development (or absence) of head structures and limbs, labial malformations, hydrops fetalis, and poor placental formation. We discussed the proposed mechanisms by which caffeine might induce these phenotypes, which may involve down-regulation of adenosine A1 receptors, and increased mothers’ catecholamines. Our findings further confirm the evidence of the teratogenic effects of high doses of caffeine administered during pregnancy. These findings support the recommendation to avoid caffeine exposure during pregnancy. Keywords: Caffeine; offspring; teratogenicity; pregnancy; hydrops; cardiovascular alterationsen-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherHCPA/FAMED/UFRGSen-US
dc.relationhttps://seer.ufrgs.br/hcpa/article/view/68287/pdf
dc.relationhttps://seer.ufrgs.br/hcpa/article/downloadSuppFile/68287/37962
dc.relationhttps://seer.ufrgs.br/hcpa/article/downloadSuppFile/68287/38719
dc.relationhttps://seer.ufrgs.br/hcpa/article/downloadSuppFile/68287/38720
dc.relationhttps://seer.ufrgs.br/hcpa/article/downloadSuppFile/68287/38721
dc.rightsDireitos autorais 2017 Clinical and Biomedical Researchpt-BR
dc.rightshttp://creativecommons.org/licenses/by/4.0pt-BR
dc.sourceClinical & Biomedical Research; v. 36, n. 4 (2016)en-US
dc.sourceClinical and Biomedical Research; v. 36, n. 4 (2016)pt-BR
dc.source2357-9730
dc.source0101-5575
dc.subjectPharmacologyen-US
dc.subjectCaffeine; offspring; teratogenicity; pregnancy; hydrops; cardiovascular alterationsen-US
dc.subjectTeratogenicityen-US
dc.titleCaffeine teratogenicity in rats: morphological characterization and hypothesized mechanismsen-US
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeAvaliado por Parespt-BR
dc.typePeer-reviewed Articleen-US


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