dc.creator | Aparicio, Jose Luis | |
dc.creator | Ottobre Saborido, Macarena Aylén | |
dc.creator | Duhalde Vega, Maite | |
dc.creator | Coutelier, Jean-Paul | |
dc.creator | Van Snick, Jacques | |
dc.creator | Retegui, Lilia Alicia | |
dc.date.accessioned | 2018-06-05T18:30:45Z | |
dc.date.accessioned | 2018-11-06T16:19:36Z | |
dc.date.available | 2018-06-05T18:30:45Z | |
dc.date.available | 2018-11-06T16:19:36Z | |
dc.date.created | 2018-06-05T18:30:45Z | |
dc.date.issued | 2017-09 | |
dc.identifier | Aparicio, Jose Luis; Ottobre Saborido, Macarena Aylén; Duhalde Vega, Maite; Coutelier, Jean-Paul; Van Snick, Jacques ; et al.; Effects of interleukin 17A (IL-17A) neutralization on murine hepatitis virus (MHV-A59) infection; John Libbey Eurotext Ltd; European Cytokine Network; 28; 3; 9-2017; 111-117 | |
dc.identifier | 1148-5493 | |
dc.identifier | http://hdl.handle.net/11336/47349 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1907047 | |
dc.description.abstract | Mice infected with mouse hepatitis virus A59 (MHV-A59) develop hepatitis and autoantibodies (autoAb) to liver and kidney fumarylacetoacetate hydrolase (FAH), a fact closely related to the release of alarmins such as uric acid and/or high-mobility group box protein 1 (HMGB1). We studied the effect of neutralizing monoclonal antibodies (MAb) against IL-17A in our model of mouse MHV-A59-infection. MAb anti IL-17F and anti-IFNγ were used to complement the study. Results showed that transaminase levels markedly decreased in MHV-A59-infected mice treated with MAb anti-IL-17A whereas plasmatic Ig concentration sharply increased. Conversely, MAb anti-IL-17F enhanced transaminase liberation and did not affect Ig levels.Serum IFNγ was detected in mice infected with MHV-A59, and its concentration increased after MAb anti-IL-17A administration. Besides, MAb anti-IFNγ greatly augmented transaminase plasmatic levels. IL-17A neutralization did not affect MHV-A59-induction of HMGB1 liberation and slightly augmented plasmatic uric acid concentration. However, mice treated with the MAb failed to produce autoAb to FAH. The above results suggest a reciprocal regulation of Th1 and Th17 cells acting on the different MHV-A59 effects. In addition, it is proposed that IL-17A is involved in alarmins adjuvant effects leading to autoAb expression. | |
dc.language | eng | |
dc.publisher | John Libbey Eurotext Ltd | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.jle.com/fr/revues/ecn/e-docs/effects_of_interleukin_17a_il_17a_neutralization_on_murine_hepatitis_virus_mhv_a59_infection_310871/article.phtml | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1684/ecn.2017.0399 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | IL-17 | |
dc.subject | IFNg | |
dc.subject | MHV | |
dc.subject | autoAb | |
dc.title | Effects of interleukin 17A (IL-17A) neutralization on murine hepatitis virus (MHV-A59) infection | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |