dc.creator | Cabral, Agustina Soledad | |
dc.creator | Portiansky, Enrique Leo | |
dc.creator | Sánchez Jaramillo, Edith | |
dc.creator | Zigman, Jeffrey M. | |
dc.creator | Perello, Mario | |
dc.date.accessioned | 2018-08-03T20:00:34Z | |
dc.date.available | 2018-08-03T20:00:34Z | |
dc.date.created | 2018-08-03T20:00:34Z | |
dc.date.issued | 2016-05 | |
dc.identifier | Cabral, Agustina Soledad; Portiansky, Enrique Leo; Sánchez Jaramillo, Edith; Zigman, Jeffrey M.; Perello, Mario; Ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus; Pergamon-Elsevier Science Ltd; Psychoneuroendocrinology; 67; 5-2016; 27-39 | |
dc.identifier | 0306-4530 | |
dc.identifier | http://hdl.handle.net/11336/54146 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.description.abstract | Previous work has established that the hormone ghrelin engages the hypothalamic-pituitary-adrenal neuroendocrine axis via activation of corticotropin-releasing factor (CRF) neurons of the hypothalamic paraventricular nucleus (PVN). The neuronal circuitry that mediates this effect of ghrelin is currently unknown. Here, we show that ghrelin-induced activation of PVN CRF neurons involved inhibition of γ-aminobutyric acid (GABA) inputs, likely via ghrelin binding sites that were localized at GABAergic terminals within the PVN. While ghrelin activated PVN CRF neurons in the presence of neuropeptide Y (NPY) receptor antagonists or in arcuate nucleus (ARC)-ablated mice, it failed to do it so in mice with ghrelin receptor expression limited to ARC agouti gene related protein (AgRP)/NPY neurons. These data support the notion that ghrelin activates PVN CRF neurons via inhibition of local GABAergic tone, in an ARC-independent manner. Furthermore, these data suggest that the neuronal circuits mediating ghrelin's orexigenic action vs. its role as a stress signal are anatomically dissociated. | |
dc.language | eng | |
dc.publisher | Pergamon-Elsevier Science Ltd | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.psyneuen.2016.01.027 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0306453016300269 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/26874559/ | |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | GHRELIN | |
dc.subject | NEUROPEPTIDE Y (NPY) | |
dc.subject | OREXIGENIC | |
dc.subject | STRESS | |
dc.subject | Γ-AMINOBUTYRIC ACID (GABA) | |
dc.title | Ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |