dc.creatorPimentel, Jerónimo
dc.creatorBoccaccio, Graciela Lidia
dc.date.accessioned2016-11-24T19:22:33Z
dc.date.accessioned2018-11-06T16:05:58Z
dc.date.available2016-11-24T19:22:33Z
dc.date.available2018-11-06T16:05:58Z
dc.date.created2016-11-24T19:22:33Z
dc.date.issued2014-07
dc.identifierPimentel, Jerónimo; Boccaccio, Graciela Lidia; Translation and Silencing in RNA Granules: a Tale of Sand Grains; Frontiers; Frontiers in Molecular Neuroscience; 7; 68; 7-2014; 1-5
dc.identifier1662-5099
dc.identifierhttp://hdl.handle.net/11336/8373
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1904590
dc.description.abstractThe transcriptome at the synapse consists of thousands of messengers encoding several cellular functions, including a significant number of receptors and ion channels and associated proteins. The concerted translational regulation of all these molecules contributes to the dynamic control of synaptic strength. Cumulative evidence supports that dendritic RNA granules and mRNA-silencing foci play an important role in translational regulation. Several relevant RBPs - FMRP; FUS/TLS; TDP-43; Staufen; Smaug; Pumilio; CPEB; HuD; ZBP1; and DDX6 among others - form granules that contain dormant mRNAs repressed by multiple pathways. Recent reports indicate that dendritic granules may contain stalled polysomes, and furthermore, active translation may occur in association with RNA granules. Here, we discuss the molecules and pathways involved in this continuum of RNA granules that contain masked mRNAs, mRNAs trapped in inactive polysomes or mRNAs engaged in translation.
dc.languageeng
dc.publisherFrontiers
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fnmol.2014.00068/full
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fnmol.2014.00068
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSTALLED POLYSOME
dc.subjectMASKING GRANULES
dc.subjectSTRESS GRANULES
dc.subjectP BODIES
dc.titleTranslation and Silencing in RNA Granules: a Tale of Sand Grains
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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