Trypanosomatid Pin1-type Peptidyl-Prolyl Isomerase is Cytosolic and Not Essential for Cell Proliferation

dc.creatorErben, Esteban Daniel
dc.creatorNardelli, Sheila
dc.creatorDe Jesus, Teresa C. L.
dc.creatorSchenkman, Sergio
dc.creatorTellez, Maria Teresa
dc.date.accessioned2016-02-02T20:46:17Z
dc.date.accessioned2018-11-06T15:56:42Z
dc.date.available2016-02-02T20:46:17Z
dc.date.available2018-11-06T15:56:42Z
dc.date.created2016-02-02T20:46:17Z
dc.date.issued2012-12-03
dc.identifierErben, Esteban Daniel; Nardelli, Sheila; De Jesus, Teresa C. L.; Schenkman, Sergio; Tellez, Maria Teresa; Trypanosomatid Pin1-type Peptidyl-Prolyl Isomerase is Cytosolic and Not Essential for Cell Proliferation; Wiley; Journal of Eukaryotic Microbiology; 60; 1; 3-12-2012; 101-105
dc.identifier1066-5234
dc.identifierhttp://hdl.handle.net/11336/3974
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1902744
dc.description.abstractPin1-type peptidyl-prolyl cis/trans isomerases (PPIases) isomerise the peptide bond of specific phosphorylated (Ser/Thr)-Pro residues, regulating various cellular events. Previously, we reported a Pin1-type PPIase in Trypanosoma cruzi, but little is known about its function and subcellular localization. Immunofluorescence analysis revealed that in contrast with Pin1-like proteins from diverse organisms, TcPin1 mainly localized in the cytoplasm and was excluded from the nuclei. In addition, RNAi-mediated downregulation of TbPin1 in Trypanosoma brucei did not abolish cell proliferation. Using yeast two-hybrid assay, we identified a MORN domain-containing protein as putative Pin1-binding partners. These data suggest that Pin1-mediated signaling mechanism plays a different role in protozoan parasites.
dc.languageeng
dc.publisherWiley
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/jeu.12009/abstract
dc.relationinfo:eu-repo/semantics/altIdentifier/issn/1066-5234
dc.relationinfo:eu-repo/semantics/altIdentifier/wos/http://dx.doi.org/DOI:10.1111/jeu.12009
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectPin1-type Peptidyl-Prolyl isomerase
dc.subjectTrypansoma cruzi
dc.titleTrypanosomatid Pin1-type Peptidyl-Prolyl Isomerase is Cytosolic and Not Essential for Cell Proliferation
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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