dc.creatorMartin, Mariana Laura
dc.creatorRodríguez Colman, María José
dc.creatorGomez Casati, Diego Fabian
dc.creatorLamattina, Lorenzo
dc.creatorZabaleta, Eduardo Julian
dc.date.accessioned2017-09-12T14:46:12Z
dc.date.available2017-09-12T14:46:12Z
dc.date.created2017-09-12T14:46:12Z
dc.date.issued2009-01
dc.identifierMartin, Mariana Laura; Rodríguez Colman, María José; Gomez Casati, Diego Fabian; Lamattina, Lorenzo; Zabaleta, Eduardo Julian; Nitric oxide accumulation is required to protect against iron-mediated oxidative stress in frataxin-deficient Arabidopsis plants; Elsevier Science; FEBS Letters; 583; 3; 1-2009; 542-548
dc.identifier0014-5793
dc.identifierhttp://hdl.handle.net/11336/23982
dc.identifierCONICET Digital
dc.identifierCONICET
dc.description.abstractFrataxin is a mitochondrial protein that is conserved throughout evolution. In yeast and mammals, frataxin is essential for cellular iron (Fe) homeostasis and survival during oxidative stress. In plants, frataxin deficiency causes increased reactive oxygen species (ROS) production and high sensitivity to oxidative stress. In this work we show that a knock-down T-DNA frataxin-deficient mutant of Arabidopsis thaliana (atfh-1) contains increased total and organellar Fe levels. Frataxin deficiency leads also to nitric oxide (NO) accumulation in both, atfh-1 roots and frataxin null mutant yeast. Abnormally high NO production might be part of the defence mechanism against Fe-mediated oxidative stress.
dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.febslet.2008.12.039
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2008.12.039/abstract
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFrataxin
dc.subjectNitric Oxide
dc.subjectOxidative Stress
dc.subjectArabidopsis Thaliana
dc.titleNitric oxide accumulation is required to protect against iron-mediated oxidative stress in frataxin-deficient Arabidopsis plants
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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