Artículos de revistas
A new depigmenting-antifungal methylated grindelane from Grindelia chiloensis
Fecha
2017-01Registro en:
Mesurado, Maria de los Angeles; Arias Cassará, María Lucrecia; Misico, Rosana Isabel; Bardon, Alicia del Valle; Ybarra, María Inés; et al.; A new depigmenting-antifungal methylated grindelane from Grindelia chiloensis; Wiley VCH Verlag; Chemistry and Biodiversity; 14; 5; 1-2017; 1-9; e1600426
1612-1872
CONICET Digital
CONICET
Autor
Mesurado, Maria de los Angeles
Arias Cassará, María Lucrecia
Misico, Rosana Isabel
Bardon, Alicia del Valle
Ybarra, María Inés
Cartagena, Elena
Resumen
The new methylated grindelane diterpenoid, 7β‐hydroxy‐8(17)‐dehydrogrindelic acid (1b), together with the known 7α‐hydroxy‐8(17)‐dehydrogrindelic acid (2a), 6‐oxogrindelic acid (3a), 4β‐hydroxy‐6‐oxo‐19‐norgrindelic (4a), 19‐hydroxygrindelic acid (5a), 18‐hydroxygrindelic acid (6a), 4α‐carboxygrindelic acid (7a), 17‐hydroxygrindelic acid (8a), 6α‐hydroxygrindelic acid (9a), 8,17‐bisnor‐8‐oxagrindelic acid (10a), 7α,8α‐epoxygrindelic acid (11a), and strictanonic acid (12a) as methyl esters were obtained from an Argentine collection of Grindelia chiloensis (Cornel.) Cabrera. Their structures and relative configurations were established on the basis of spectroscopic analysis. CHCl3 extract from the aerial parts and their pure compounds were evaluated for their antifungal and depigmenting effects. Methyl ester derivative of 10a (10b) exhibited a remarkable mycelial growth inhibition against Botritis cinerea with an IC50 of 13.5 μg ml−1. While the new grindelane 1b exerted a clear color reduction of the yellow‐orange pigment developed by Fusarium oxysporum against UV‐induced damage.