Receptor-mediated endocytosis and trafficking between endosomal–lysosomal vacuoles in Giardia lamblia

dc.creatorRivero, Maria Romina
dc.creatorJausoro, Ignacio
dc.creatorBisbal, Mariano
dc.creatorFeliziani, Constanza
dc.creatorLanfredi Rangel, Adriana
dc.creatorTouz, Maria Carolina
dc.date.accessioned2016-12-06T16:52:45Z
dc.date.accessioned2018-11-06T15:46:25Z
dc.date.available2016-12-06T16:52:45Z
dc.date.available2018-11-06T15:46:25Z
dc.date.created2016-12-06T16:52:45Z
dc.date.issued2013-04
dc.identifierRivero, Maria Romina; Jausoro, Ignacio; Bisbal, Mariano; Feliziani, Constanza; Lanfredi Rangel, Adriana; et al.; Receptor-mediated endocytosis and trafficking between endosomal–lysosomal vacuoles in Giardia lamblia; Springer; Parasitology Research; 112; 4; 4-2013; 1813-1818
dc.identifier0932-0113
dc.identifierhttp://hdl.handle.net/11336/8896
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1900846
dc.description.abstractThe early branching Giardia lamblia has highly polarized vacuoles, located underneath the plasma membrane, which have at least some of the characteristics of endosomes and of lysosomes. These peripheral vacuoles (PVs) are necessary for nutrient uptake and the maintenance of plasma membrane composition, but whether they carry out sorting and segregation of receptors and ligands is a matter of debate. Here, we showed that the internalization of low-density lipoprotein (LDL) to the PVs is highly dynamic in trophozoites with a rate similar to the internalization of the low-density lipoprotein receptor-related protein 1. Moreover, by analyzing receptor-mediated and fluid-phase endocytosis in living cells, we showed that after endocytosis LDL but not dextran moved laterally between the PVs. We speculate on PV functional heterogeneity and maturation in this parasite.
dc.languageeng
dc.publisherSpringer
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00436-012-3253-7
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600075/
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs00436-012-3253-7
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGIARDIA i
dc.subjectLAMBLIA
dc.subjectENDOCYTOSIS
dc.subjectTIRF
dc.titleReceptor-mediated endocytosis and trafficking between endosomal–lysosomal vacuoles in Giardia lamblia
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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