dc.creator | Cardama, Georgina Alexandra | |
dc.creator | González, Nazareno | |
dc.creator | Maggio, J. | |
dc.creator | Lorenzano Menna, Pablo | |
dc.creator | Gomez, Daniel Eduardo | |
dc.date.accessioned | 2018-04-18T16:03:40Z | |
dc.date.accessioned | 2018-11-06T15:45:44Z | |
dc.date.available | 2018-04-18T16:03:40Z | |
dc.date.available | 2018-11-06T15:45:44Z | |
dc.date.created | 2018-04-18T16:03:40Z | |
dc.date.issued | 2017-10 | |
dc.identifier | Cardama, Georgina Alexandra; González, Nazareno; Maggio, J.; Lorenzano Menna, Pablo; Gomez, Daniel Eduardo; Rho GTPases as therapeutic targets in cancer (Review); Spandidos Publications; International Journal of Oncology; 51; 4; 10-2017; 1025-1034 | |
dc.identifier | 1019-6439 | |
dc.identifier | http://hdl.handle.net/11336/42472 | |
dc.identifier | 1791-2423 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1900713 | |
dc.description.abstract | Rho GTPases are key molecular switches controlling the transduction of external signals to cytoplasmic and nuclear effectors. In the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the specific roles of Rho GTPases in cancer. The aim of the present review is to describe the cellular functions regulated by these proteins with focus in deregulated signals present in malignant tumors. Finally, we describe the state of the art in search of different experimental therapeutic strategies with Rho GTPases as molecular targets. | |
dc.language | eng | |
dc.publisher | Spandidos Publications | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.spandidos-publications.com/10.3892/ijo.2017.4093 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3892/ijo.2017.4093 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | RHO GTPases | |
dc.subject | Therapeutic targets | |
dc.subject | Cancer | |
dc.subject | Drug design | |
dc.title | Rho GTPases as therapeutic targets in cancer (Review) | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |