Rho GTPases as therapeutic targets in cancer (Review)

dc.creatorCardama, Georgina Alexandra
dc.creatorGonzález, Nazareno
dc.creatorMaggio, J.
dc.creatorLorenzano Menna, Pablo
dc.creatorGomez, Daniel Eduardo
dc.date.accessioned2018-04-18T16:03:40Z
dc.date.accessioned2018-11-06T15:45:44Z
dc.date.available2018-04-18T16:03:40Z
dc.date.available2018-11-06T15:45:44Z
dc.date.created2018-04-18T16:03:40Z
dc.date.issued2017-10
dc.identifierCardama, Georgina Alexandra; González, Nazareno; Maggio, J.; Lorenzano Menna, Pablo; Gomez, Daniel Eduardo; Rho GTPases as therapeutic targets in cancer (Review); Spandidos Publications; International Journal of Oncology; 51; 4; 10-2017; 1025-1034
dc.identifier1019-6439
dc.identifierhttp://hdl.handle.net/11336/42472
dc.identifier1791-2423
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1900713
dc.description.abstractRho GTPases are key molecular switches controlling the transduction of external signals to cytoplasmic and nuclear effectors. In the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the specific roles of Rho GTPases in cancer. The aim of the present review is to describe the cellular functions regulated by these proteins with focus in deregulated signals present in malignant tumors. Finally, we describe the state of the art in search of different experimental therapeutic strategies with Rho GTPases as molecular targets.
dc.languageeng
dc.publisherSpandidos Publications
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.spandidos-publications.com/10.3892/ijo.2017.4093
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3892/ijo.2017.4093
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRHO GTPases
dc.subjectTherapeutic targets
dc.subjectCancer
dc.subjectDrug design
dc.titleRho GTPases as therapeutic targets in cancer (Review)
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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