dc.creatorMartorelli, Luisina
dc.creatorHovde, C. J.
dc.creatorVilte, D. A.
dc.creatorAlbanese, A.
dc.creatorZotta, E.
dc.creatorIbarra, Cristina Adriana
dc.creatorCantet, Rodolfo Juan Carlos
dc.creatorMercado, E. C.
dc.creatorCataldi, Angel Adrian
dc.date.accessioned2017-05-19T19:32:02Z
dc.date.accessioned2018-11-06T15:44:36Z
dc.date.available2017-05-19T19:32:02Z
dc.date.available2018-11-06T15:44:36Z
dc.date.created2017-05-19T19:32:02Z
dc.date.issued2015
dc.identifierMartorelli, Luisina; Hovde, C. J.; Vilte, D. A.; Albanese, A.; Zotta, E.; et al.; Impact of infection dose and previous serum antibodies against the Locus of Enterocyte effacement proteins on Escherichia Coli O157:H7 shedding in calves following experimental infection; Hindawi Publishing Corporation; BioMed Research International; 2015; -1-2015; 1-8; 290679
dc.identifier2314-6133
dc.identifierhttp://hdl.handle.net/11336/16763
dc.identifier2314-6141
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1900489
dc.description.abstractEscherichia coli O157:H7 is the main causative agent of haemolytic uremic syndrome. Cattle are the main reservoir of these bacteria, and have been shown to develop immune response to colonization. Our aim was to investigate the faecal shedding pattern of E. coli O157:H7 in calves challenged intragastrically with either 108 or 1010 CFU, as well as the ability of specific preexisting antibodies to reduce shedding of the pathogen. Shedding was analysed by direct counting as well as enrichment of rectoanal mucosal swabs. Statistical analysis was performed using a linear model for repeated measures with and without the inclusion of preexisting antibodies against the carboxy-terminal fraction of intimin- (-intimin C280) as a covariable. Results suggest that there is a statistical difference in the area under the shedding curves between both doses for 14 as well as 28 days after challenge (p = 0.0069 and 0.0209, resp.). This difference is increased when the prechallenge antibodies are taken into account (p = 0.0056 and 0.0185). We concluded that the bacterial dose influences shedding on calves experimentally challenged and that preexisting antibodies against E. coli O157:H7 -intimin C280 could partially reduce faecal excretion.
dc.languageeng
dc.publisherHindawi Publishing Corporation
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2015/290679
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2015/290679/
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectE. coli O157:H7
dc.subjectCalves
dc.subjectExperimental infection
dc.subjectAntibodies anti-LEE
dc.titleImpact of infection dose and previous serum antibodies against the Locus of Enterocyte effacement proteins on Escherichia Coli O157:H7 shedding in calves following experimental infection
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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