info:eu-repo/semantics/article
Brucella alters the immune response in a prpA-dependent manner
Fecha
2014-01Registro en:
Spera, Juan Manuel; Comerci, Diego José; Ugalde, Juan Esteban; Brucella alters the immune response in a prpA-dependent manner; Academic Press Ltd-elsevier Science Ltd; Microbial Pathogenesis; 67-68; 1-2014; 8-13
0882-4010
CONICET Digital
CONICET
Autor
Spera, Juan Manuel
Comerci, Diego José
Ugalde, Juan Esteban
Resumen
Brucellosis, a disease caused by the gram-negative bacterium Brucella spp., is a widespread zoonosis that inflicts important animal and human health problems, especially in developing countries. One of the hallmarks of Brucella infection is its capacity to establish a chronic infection, characteristic that depends on a wide repertoire of virulence factors among which are immunomodulatory proteins such as PrpA (encoding the proline racemase protein A or hydroxyproline-2-epimerase), involved in the establishment of the chronic phase of the infectious process that we have previously identified and characterized. We report here that, in vivo, Brucella abortus prpA is responsible for an increment in the B-cell number and in the specific antibody response and that these antibodies promote cell infection. We additionally found that Brucella alters the cytokine levels of IFN-γ, IL-10, TGFβ1 and TNFα during the acute phase of the infectious process in a prpA dependent manner.