dc.creatorFernández, María Laura
dc.creatorRisk, Marcelo Raúl
dc.creatorVernier, P. Thomas
dc.date.accessioned2018-08-30T14:14:31Z
dc.date.accessioned2018-11-06T15:41:00Z
dc.date.available2018-08-30T14:14:31Z
dc.date.available2018-11-06T15:41:00Z
dc.date.created2018-08-30T14:14:31Z
dc.date.issued2017-11
dc.identifierFernández, María Laura; Risk, Marcelo Raúl; Vernier, P. Thomas; Electropore Formation in Mechanically Constrained Phospholipid Bilayers; Springer; Journal of Membrane Biology; 251; 2; 11-2017; 237-245
dc.identifier0022-2631
dc.identifierhttp://hdl.handle.net/11336/57647
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1899754
dc.description.abstractMolecular dynamics simulations of lipid bilayers in aqueous systems reveal how an applied electric field stabilizes the reorganization of the water–membrane interface into water-filled, membrane-spanning, conductive pores with a symmetric, toroidal geometry. The pore formation process and the resulting symmetric structures are consistent with other mathematical approaches such as continuum models formulated to describe the electroporation process. Some experimental data suggest, however, that the shape of lipid electropores in living cell membranes may be asymmetric. We describe here the axially asymmetric pores that form when mechanical constraints are applied to selected phospholipid atoms. Electropore formation proceeds even with severe constraints in place, but pore shape and pore formation time are affected. Since lateral and transverse movement of phospholipids may be restricted in cell membranes by covalent attachments to or non-covalent associations with other components of the membrane or to membrane-proximate intracellular or extracellular biomolecular assemblies, these lipid-constrained molecular models point the way to more realistic representations of cell membranes in electric fields.
dc.languageeng
dc.publisherSpringer
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/10.1007/s00232-017-0002-y
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00232-017-0002-y
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectELECTROPORATION
dc.subjectMOLECULAR DYNAMICS
dc.subjectPHOSPHOLIPID BILAYER
dc.subjectPOSITION CONSTRAINTS
dc.titleElectropore Formation in Mechanically Constrained Phospholipid Bilayers
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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