dc.creatorMontalto, Maria
dc.creatorBartel, L. C.
dc.creatorCastro, Jose Alberto
dc.date.accessioned2016-09-06T20:54:22Z
dc.date.accessioned2018-11-06T15:33:09Z
dc.date.available2016-09-06T20:54:22Z
dc.date.available2018-11-06T15:33:09Z
dc.date.created2016-09-06T20:54:22Z
dc.date.issued2013-12
dc.identifierMontalto, Maria; Bartel, L. C.; Castro, Jose Alberto; Effect of chronic alcohol drinking on rat liver microsomal nitroreductive metabolism of Nifurtimox and Benznidazole; Sage Publications Ltd; Human and Experimental Toxicoloxy; 32; 12; 12-2013; 1305-1310
dc.identifier0960-3271
dc.identifierhttp://hdl.handle.net/11336/7506
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1898421
dc.description.abstractNifurtimox (Nfx) and benznidazole (Bz) have serious toxic side effects. Manufacturers warn about significant adverse effects when simultaneous alcohol consumption is being made, but its mechanism is not known. The levels and toxicity of these drugs are linked to their liver microsomal nitroreduction to reactive metabolites. In this study, we analyzed whether alcohol drinking enhanced those nitroreductive processes. Male and female Sprague-Dawley rats, 5–6 weeks old (125–150 g body weight) were used. They were fed ad libitum for 28 days with Lieber and De Carli control or alcohol regular liquid diets. The rats were separated into two dietary groups: ethanol and control group. Both were pair fed with the respective diet. Their liver microsomes were isolated and the nicotinamide adenine dinucleotide phosphate-dependent nitroreduction of Nfx and Bz were determined. Alcohol drinking significantly induced microsomal nitroreduction of these drugs in male rats (11% for Nfx and 41% for Bz) but not in females. The activity observed in the alcohol-induced male rats was 100% inhibited by diphenyleneiodonium and attributable to P450 reductase. Inductive effects of alcohol drinking on nitroreductive activation of both drugs might be only partially involved in the harmful interactions described.
dc.languageeng
dc.publisherSage Publications Ltd
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://het.sagepub.com/content/32/12/1305.long
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1177/0960327113485254
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectALCOHOL DRINKING
dc.subjectNIFURTIMOX
dc.subjectBENZNIDAZOLE
dc.subjectLIVER MICROSOMES
dc.subjectNITROREDUCTION
dc.titleEffect of chronic alcohol drinking on rat liver microsomal nitroreductive metabolism of Nifurtimox and Benznidazole
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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