Artículos de revistas
Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus
Fecha
2012-12-17Registro en:
Careaga Quiroga, Valeria Pilar; Bueno, Carlos Alberto; Muniain, Claudia Cristina; Alche, Laura Edith; Maier, Marta Silvia; Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus; Taylor & Francis; Natural Product Research; 28; 4; 17-12-2012; 2213-220
1478-6419
Autor
Careaga Quiroga, Valeria Pilar
Bueno, Carlos Alberto
Muniain, Claudia Cristina
Alche, Laura Edith
Maier, Marta Silvia
Resumen
A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis (1H and 13C NMR, 1H,1H-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemical transformations. In addition, the cytotoxicity and antiproliferative activities of 1 and structurally related triterpene glycosides isolated from the sea cucumbers Psolus patagonicus and Hemioedema spectabilis were evaluated against cancer cell lines A-549 and HeLa.