info:eu-repo/semantics/article
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity
Fecha
2016-04Registro en:
Chan, Pamela Y.; Carrera Silva, Eugenio Antonio; De Kouchkovsky, Dimitri; Joannas, Leonel D.; Hao, Liming; et al.; The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity; American Association for the Advancement of Science; Science; 352; 6281; 4-2016; 99-103
0036-8075
1095-9203
CONICET Digital
CONICET
Autor
Chan, Pamela Y.
Carrera Silva, Eugenio Antonio
De Kouchkovsky, Dimitri
Joannas, Leonel D.
Hao, Liming
Hu, Donglei
Huntsman, Scott
Eng, Celeste
Licona Limón, Paula
Weinstein, Jason S.
De Broski, Herbert R.
Craft , Joseph E.
Flavell, Richard A.
Repetto, Silvia
Correale, Jorge
Burchard, Esteban G.
Torgerson, Dora G.
Ghosh, Sourav
Rothlin, Carla V.
Resumen
Host responses against metazoan parasites or an array of environmental substances elicit type 2 immunity. Despite its protective function, type 2 immunity also drives allergic diseases. The mechanisms that regulate the magnitude of the type 2 response remain largely unknown. Here, we show that genetic ablation of a receptor tyrosine kinase encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity. Furthermore, the TYRO3 agonist PROS1 was induced in T cells by the quintessential type 2 cytokine, interleukin-4. T cell-specificPros1knockouts phenocopied the loss ofTyro3 Thus, a PROS1-mediated feedback from adaptive immunity engages a rheostat, TYRO3, on innate immune cells to limit the intensity of type 2 responses.