dc.creator | Ossola, César Ángel | |
dc.creator | Surkin, Pablo Nicolas | |
dc.creator | Pugnaloni, Antonela | |
dc.creator | Mohn, Claudia Ester | |
dc.creator | Elverdin, Juan Carlos | |
dc.creator | Fernández Solari, Jose Javier | |
dc.date.accessioned | 2017-05-12T16:00:29Z | |
dc.date.accessioned | 2018-11-06T15:10:38Z | |
dc.date.available | 2017-05-12T16:00:29Z | |
dc.date.available | 2018-11-06T15:10:38Z | |
dc.date.created | 2017-05-12T16:00:29Z | |
dc.date.issued | 2012-09 | |
dc.identifier | Ossola, César Ángel; Surkin, Pablo Nicolas; Pugnaloni, Antonela; Mohn, Claudia Ester; Elverdin, Juan Carlos; et al.; Long-term treatment with methanandamide attenuates LPS-induced periodontitis in rats; Birkhauser Verlag Ag; Inflammation Research; 61; 9; 9-2012; 941-948 | |
dc.identifier | 1023-3830 | |
dc.identifier | http://hdl.handle.net/11336/16385 | |
dc.identifier | 1420-908X | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1894361 | |
dc.description.abstract | OBJECTIVE: Evidence exists of the anti-inflammatory and immunological properties of endocannabinoids in various tissues; the aim of the present study was therefore to assess the effect of long-term treatment with the synthetic cannabinoid methanandamide (Meth-AEA) on the progression of periodontitis in rats. MATERIALS AND METHODS: Periodontitis was induced by injecting LPS (1 mg/ml) into the gingiva around the neck of the first upper and lower molars, and into the inter-dental space between the first and second molars. This protocol was repeated for 6 weeks on days 1, 3, and 5 of each week. RESULTS: Long-term treatment with topical Meth-AEA (500 ng/ml), applied daily to gingival tissue of rats induced with periodontitis, significantly diminished the alveolar bone loss, measured as the distance between the cemento-enamel junction and the alveolar crest, in both maxillary and mandibular first molars, compared to rats without treatment (P < 0.05). The treatment also reduced the production of some biological mediators of periodontal disease augmented by LPS, such as tumor necrosis factor alpha (from 119.4 ± 9.9 pg/mg protein to 75.1 ± 10.8, P < 0.05) and nitric oxide produced by inducible nitric oxide synthase (from 507.7 ± 107.1 pmol/min/mg protein to 163.1 ± 53.9, P < 0.01). CONCLUSION: These results demonstrate the beneficial effects of treatment with Meth-AEA on gingival tissue of rats with periodontitis. | |
dc.language | eng | |
dc.publisher | Birkhauser Verlag Ag | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00011-012-0485-z | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00011-012-0485-z | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | OXYGEN RADICALS | |
dc.subject | LIPOPOLYSACCHARIDE | |
dc.subject | BONE INJURY | |
dc.subject | TUMOR NECROSIS FACTOR | |
dc.subject | PROSTAGLANDINS | |
dc.title | Long-term treatment with methanandamide attenuates LPS-induced periodontitis in rats | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |