Polyhydroxylated sulfated steroids derived from 5α-cholestanes as antiviral agents against herpes simplex virus

dc.creatorPujol, Carlos Alberto
dc.creatorSepúlveda, Claudia Soledad
dc.creatorRichmond, Victoria
dc.creatorMaier, Marta Silvia
dc.creatorDamonte, Elsa Beatriz
dc.date.accessioned2018-09-13T18:59:42Z
dc.date.available2018-09-13T18:59:42Z
dc.date.created2018-09-13T18:59:42Z
dc.date.issued2016-07
dc.identifierPujol, Carlos Alberto; Sepúlveda, Claudia Soledad; Richmond, Victoria; Maier, Marta Silvia; Damonte, Elsa Beatriz; Polyhydroxylated sulfated steroids derived from 5α-cholestanes as antiviral agents against herpes simplex virus; Springer Wien; Archives of Virology; 161; 7; 7-2016; 1993-1999
dc.identifier0304-8608
dc.identifierhttp://hdl.handle.net/11336/59597
dc.identifierCONICET Digital
dc.identifierCONICET
dc.description.abstractTwelve polyhydroxylated sulfated steroids synthesized from a 5α-cholestane skeleton with different substitutions in C-2, C-3 and C-6 were evaluated for cytotoxicity and antiviral activity against herpes simplex virus (HSV) by a virus plaque reduction assay. Four compounds elicited a selective inhibitory effect against HSV. The disodium salt of 2β,3α-dihydroxy-6E-hydroximine-5α-cholestane-2,3-disulfate, named compound 7, was the most effective inhibitor of HSV-1, HSV-2 and pseudorabies virus (PrV) strains, including acyclovir-resistant variants, in human and monkey cell lines. Preliminary mechanistic studies demonstrated that compound 7 did not affect the initial steps of virus entry but inhibited a subsequent event in the infection process of HSV.
dc.languageeng
dc.publisherSpringer Wien
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1007/s00705-016-2867-y
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00705-016-2867-y
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject5Α-Cholestanes
dc.subjectAntiviral Activity
dc.subjectHerpes Simplex Virus
dc.subjectPolyhydroxylated Sulfated Steroids
dc.titlePolyhydroxylated sulfated steroids derived from 5α-cholestanes as antiviral agents against herpes simplex virus
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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