Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA

dc.creatorGarabalino, Marcela Alejandra
dc.creatorHeber, Elisa Mercedes
dc.creatorMonti Hughes, Andrea
dc.creatorPozzi, Emiliano César Cayetano
dc.creatorMolinari, Ana Julia
dc.creatorNigg, David W.
dc.creatorBauer, William
dc.creatorTrivillin, Verónica Andrea
dc.creatorSchwint, Amanda Elena
dc.date.accessioned2017-09-13T13:09:42Z
dc.date.accessioned2018-11-06T15:00:31Z
dc.date.available2017-09-13T13:09:42Z
dc.date.available2018-11-06T15:00:31Z
dc.date.created2017-09-13T13:09:42Z
dc.date.issued2013-12
dc.identifierGarabalino, Marcela Alejandra; Heber, Elisa Mercedes; Monti Hughes, Andrea; Pozzi, Emiliano César Cayetano; Molinari, Ana Julia; et al.; Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA; Elsevier; Applied Radiation and Isotopes; 88; 12-2013; 64-68
dc.identifier0969-8043
dc.identifierhttp://hdl.handle.net/11336/24103
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1892761
dc.description.abstractSodium mercaptoundecahydro-closo-dodecaborate (BSH) is being investigated clinically for BNCT. We examined the biodistribution of BSH and BPA administered jointly in different proportions in the hamster cheek pouch oral cancer model. The 3 assayed protocols were non-toxic, and showed preferential tumor boron uptake versus precancerous and normal tissue and therapeutic tumor boron concentration values (70-85ppm). All 3 protocols warrant assessment in BNCT studies to contribute to the knowledge of (BSH+BPA)-BNCT radiobiology for head and neck cancer and optimize therapeutic efficacy.
dc.languageeng
dc.publisherElsevier
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.apradiso.2013.11.118
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0969804313005678
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBoron Neutron Capture Therapy
dc.subjectBNCT
dc.subjectOral cancer
dc.subjectBPA
dc.subjectBSH
dc.subjectHamster cheek pouch oral cancer model
dc.titleBoron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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