dc.creatorAlvarez, Diego
dc.creatorGiacomini, Damiana Paula
dc.creatorYang, Sung Min
dc.creatorTrinchero, Mariela Fernanda
dc.creatorTemprana, Silvio Gabriel
dc.creatorBüttner, Karina A.
dc.creatorBeltramone, Natalia
dc.creatorSchinder, Alejandro Fabián
dc.date.accessioned2017-09-18T19:18:10Z
dc.date.accessioned2018-11-06T14:47:25Z
dc.date.available2017-09-18T19:18:10Z
dc.date.available2018-11-06T14:47:25Z
dc.date.created2017-09-18T19:18:10Z
dc.date.issued2016-10
dc.identifierAlvarez, Diego; Giacomini, Damiana Paula; Yang, Sung Min; Trinchero, Mariela Fernanda; Temprana, Silvio Gabriel; et al.; A disynaptic feedback network activated by experience promotes the integration of new granule cells; American Association for the Advancement of Science; Science; 354; 6311; 10-2016; 459-465
dc.identifier0036-8075
dc.identifierhttp://hdl.handle.net/11336/24481
dc.identifier1095-9203
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1890335
dc.description.abstractExperience shapes the development and connectivity of adult-born granule cells (GCs) through mechanisms that are poorly understood. We examined the remodeling of dentate gyrus microcircuits in mice in an enriched environment (EE). Short exposure to EE during early development of new GCs accelerated their functional integration. This effect was mimicked by in vivo chemogenetic activation of a limited population of mature GCs. Slice recordings showed that mature GCs recruit parvalbumin γ-aminobutyric acid-releasing interneurons (PV-INs) that feed back onto developing GCs. Accordingly, chemogenetic stimulation of PV-INs or direct depolarization of developing GCs accelerated GC integration, whereas inactivation of PV-INs prevented the effects of EE. Our results reveal a mechanism for dynamic remodeling in which experience activates dentate networks that "prime" young GCs through a disynaptic feedback loop mediated by PV-INs.
dc.languageeng
dc.publisherAmerican Association for the Advancement of Science
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://science.sciencemag.org/content/354/6311/459.long
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1126/science.aaf2156
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectADULT NEUROGENESIS
dc.subjectDISYNAPTIC FEEDBACK
dc.subjectEXPERIENCE
dc.subjectDENTATE GYRUS
dc.titleA disynaptic feedback network activated by experience promotes the integration of new granule cells
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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