dc.creator | Fernandez, Macarena Soledad | |
dc.creator | Fabio, Maria Carolina | |
dc.creator | Miranda Morales, Roberto Sebastián | |
dc.creator | Virgolini, Miriam Beatriz | |
dc.creator | de Giovanni, Laura Noemi | |
dc.creator | Hansen, Cristian | |
dc.creator | Wille-bille, Aranza | |
dc.creator | Nizhnikov, Michael | |
dc.creator | Spear, Linda P. | |
dc.creator | Pautassi, Ricardo Marcos | |
dc.date.accessioned | 2018-07-05T14:09:26Z | |
dc.date.accessioned | 2018-11-06T14:47:14Z | |
dc.date.available | 2018-07-05T14:09:26Z | |
dc.date.available | 2018-11-06T14:47:14Z | |
dc.date.created | 2018-07-05T14:09:26Z | |
dc.date.issued | 2016-03 | |
dc.identifier | Fernandez, Macarena Soledad; Fabio, Maria Carolina; Miranda Morales, Roberto Sebastián; Virgolini, Miriam Beatriz; de Giovanni, Laura Noemi; et al.; Age-related effects of chronic restraint stress on ethanol drinking, ethanol-induced sedation, and on basal and stress-induced anxiety response; Elsevier Science Inc; Alcohol; 51; 3-2016; 89-100 | |
dc.identifier | 0741-8329 | |
dc.identifier | http://hdl.handle.net/11336/51304 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1890289 | |
dc.description.abstract | Adolescents are sensitive to the anxiolytic effect of ethanol, and evidence suggests that they may be more sensitive to stress than adults. Relatively little is known, however, about age-related differences in stress modulation of ethanol drinking or stress modulation of ethanol-induced sedation and hypnosis. We observed that chronic restraint stress transiently exacerbated free-choice ethanol drinking in adolescent, but not in adult, rats. Restraint stress altered exploration patterns of a light-dark box apparatus in adolescents and adults. Stressed animals spent significantly more time in the white area of the maze and made significantly more transfers between compartments than their non-stressed peers. Behavioral response to acute stress, on the other hand, was modulated by prior restraint stress only in adults. Adolescents, unlike adults, exhibited ethanol-induced motor stimulation in an open field. Stress increased the duration of loss of the righting reflex after a high ethanol dose, yet this effect was similar at both ages. Ethanol-induced sleep time was much higher in adult than in adolescent rats, yet stress diminished ethanol-induced sleep time only in adults. The study indicates age-related differences that may increase the risk for initiation and escalation in alcohol drinking. | |
dc.language | eng | |
dc.publisher | Elsevier Science Inc | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.alcohol.2015.11.009 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0741832915300562 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | ADOLESCENT | |
dc.subject | ADULT | |
dc.subject | ETHANOL | |
dc.subject | RAT | |
dc.subject | RESTRAINT STRESS | |
dc.title | Age-related effects of chronic restraint stress on ethanol drinking, ethanol-induced sedation, and on basal and stress-induced anxiety response | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |