dc.creatorFernandez, Macarena Soledad
dc.creatorFabio, Maria Carolina
dc.creatorMiranda Morales, Roberto Sebastián
dc.creatorVirgolini, Miriam Beatriz
dc.creatorde Giovanni, Laura Noemi
dc.creatorHansen, Cristian
dc.creatorWille-bille, Aranza
dc.creatorNizhnikov, Michael
dc.creatorSpear, Linda P.
dc.creatorPautassi, Ricardo Marcos
dc.date.accessioned2018-07-05T14:09:26Z
dc.date.accessioned2018-11-06T14:47:14Z
dc.date.available2018-07-05T14:09:26Z
dc.date.available2018-11-06T14:47:14Z
dc.date.created2018-07-05T14:09:26Z
dc.date.issued2016-03
dc.identifierFernandez, Macarena Soledad; Fabio, Maria Carolina; Miranda Morales, Roberto Sebastián; Virgolini, Miriam Beatriz; de Giovanni, Laura Noemi; et al.; Age-related effects of chronic restraint stress on ethanol drinking, ethanol-induced sedation, and on basal and stress-induced anxiety response; Elsevier Science Inc; Alcohol; 51; 3-2016; 89-100
dc.identifier0741-8329
dc.identifierhttp://hdl.handle.net/11336/51304
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1890289
dc.description.abstractAdolescents are sensitive to the anxiolytic effect of ethanol, and evidence suggests that they may be more sensitive to stress than adults. Relatively little is known, however, about age-related differences in stress modulation of ethanol drinking or stress modulation of ethanol-induced sedation and hypnosis. We observed that chronic restraint stress transiently exacerbated free-choice ethanol drinking in adolescent, but not in adult, rats. Restraint stress altered exploration patterns of a light-dark box apparatus in adolescents and adults. Stressed animals spent significantly more time in the white area of the maze and made significantly more transfers between compartments than their non-stressed peers. Behavioral response to acute stress, on the other hand, was modulated by prior restraint stress only in adults. Adolescents, unlike adults, exhibited ethanol-induced motor stimulation in an open field. Stress increased the duration of loss of the righting reflex after a high ethanol dose, yet this effect was similar at both ages. Ethanol-induced sleep time was much higher in adult than in adolescent rats, yet stress diminished ethanol-induced sleep time only in adults. The study indicates age-related differences that may increase the risk for initiation and escalation in alcohol drinking.
dc.languageeng
dc.publisherElsevier Science Inc
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.alcohol.2015.11.009
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0741832915300562
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectADOLESCENT
dc.subjectADULT
dc.subjectETHANOL
dc.subjectRAT
dc.subjectRESTRAINT STRESS
dc.titleAge-related effects of chronic restraint stress on ethanol drinking, ethanol-induced sedation, and on basal and stress-induced anxiety response
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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