dc.creator | Galletti, Jeremías Gastón | |
dc.creator | Gabelloni, María Laura | |
dc.creator | Morande, Pablo Elías | |
dc.creator | Sabbione, Florencia | |
dc.creator | Vermeulen, Elba Monica | |
dc.creator | Trevani, Analía Silvina | |
dc.creator | Giordano, Mirta Nilda | |
dc.date.accessioned | 2018-07-27T18:17:36Z | |
dc.date.accessioned | 2018-11-06T14:34:20Z | |
dc.date.available | 2018-07-27T18:17:36Z | |
dc.date.available | 2018-11-06T14:34:20Z | |
dc.date.created | 2018-07-27T18:17:36Z | |
dc.date.issued | 2012-06 | |
dc.identifier | Galletti, Jeremías Gastón; Gabelloni, María Laura; Morande, Pablo Elías; Sabbione, Florencia; Vermeulen, Elba Monica; et al.; Benzalkonium chloride breaks down conjunctival immunological tolerance in a murine model; Nature Publishing Group; Mucosal Immunology; 6; 1; 6-2012; 24-34 | |
dc.identifier | 1933-0219 | |
dc.identifier | http://hdl.handle.net/11336/53314 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1887842 | |
dc.description.abstract | The impact of topical eye drops with benzalkonium chloride (BAK) as a preservative could involve more than the reported toxic effects on the ocular surface epithelium and ultimately affect the immune balance of the conjunctiva. We found that BAK not only impairs tolerance induction in a murine model, but leads to mild systemic immunization. Contrasting with antigen only-treated mice, there was no induction of interleukin 10-producing antigen-specific CD4 + cells in BAK-treated animals. Moreover, the tolerogenic capacity of migrating dendritic cells (DCs) was reduced, apparently involving differential conditioning by soluble epithelial factors. Accordingly, epithelial cells exposed in vitro to BAK were less suppressive and failed to induce tolerogenic DCs in culture. As this effect of BAK was dependent on epithelial nuclear factor κB pathway activation, our findings may provide new therapeutic targets. Thus, tolerance breakdown by BAK should be considered an important factor in the management of glaucoma and immune-mediated ocular surface disorders. © 2013 Society for Mucosal Immunology. | |
dc.language | eng | |
dc.publisher | Nature Publishing Group | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1038/mi.2012.44 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/mi201244 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | BENZALKONIUM | |
dc.subject | TOLERANCE | |
dc.subject | IMMUNOLOGY | |
dc.subject | CONJUNTIVA | |
dc.title | Benzalkonium chloride breaks down conjunctival immunological tolerance in a murine model | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |