Artículos de revistas
Alternative splicing: a pivotal step between eukaryotic transcription and translation
Kornblihtt, Alberto Rodolfo; Schor, Ignacio Esteban; Alló, Mariano; Dujardin, Gwendal; Petrillo, Ezequiel; et al.; Alternative splicing: a pivotal step between eukaryotic transcription and translation; Nature Publishing Group; Nature Reviews Molecular Cell Biology; 14; 3-2013; 153-165
Kornblihtt, Alberto Rodolfo
Schor, Ignacio Esteban
Muñoz, Manuel Javier
Alternative splicing was discovered simultaneously with splicing over three decades ago. Since then, an enormous body of evidence has demonstrated the prevalence of alternative splicing in multicellular eukaryotes, its key roles in determining tissue- and species-specific differentiation patterns, the multiple post- and co-transcriptional regulatory mechanisms that control it, and its causal role in hereditary disease and cancer. The emerging evidence places alternative splicing in a central position in the flow of eukaryotic genetic information, between transcription and translation, in that it can respond not only to various signalling pathways that target the splicing machinery but also to transcription factors and chromatin structure.