Artículos de revistas
Comparative plasma exposure of albendazole after administration of rapid disintegrating tablets in dogs
Fecha
2013-07Registro en:
Castro, Silvina Gabriela; Dib, Alicia; Suarez, Gonzalo; Allemandi, Daniel Alberto; Lanusse, Carlos Edmundo; et al.; Comparative plasma exposure of albendazole after administration of rapid disintegrating tablets in dogs; Hindawi Publishing Corporation; Biomed Research International; 2013; 7-2013; 920305-920305
2314-6141
Autor
Castro, Silvina Gabriela
Dib, Alicia
Suarez, Gonzalo
Allemandi, Daniel Alberto
Lanusse, Carlos Edmundo
Sanchez Bruni, Sergio Fabian
Palma, Santiago Daniel
Resumen
The main objectives of this study were (a) to evaluate the in vitro performance of the rapid disintegration tablets as a way to improve the solid dispersions and (b) to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs. Rapid disintegration of tablets seems to be a key factor for efficiency of solid dispersions with regard to improvement of the albendazole bioavailability. The in vivo assays performed on dogs showed a marked increase in drug plasma exposure when albendazole was given in solid dispersions incorporated into rapid disintegration tablets compared with conventional solid dosage form.