Mechanism-Based Solution to the ProTide Synthesis Problem: Selective Access to Sofosbuvir, Acelarin, and INX-08189

dc.creatorSimmons, Bryon
dc.creatorLiu, Zhuqing
dc.creatorKlapars, Artis
dc.creatorBellomo Peraza, Ana Ines
dc.creatorSilverman, Steven M.
dc.date.accessioned2018-07-04T15:24:13Z
dc.date.accessioned2018-11-06T14:24:01Z
dc.date.available2018-07-04T15:24:13Z
dc.date.available2018-11-06T14:24:01Z
dc.date.created2018-07-04T15:24:13Z
dc.date.issued2017-05
dc.identifierSimmons, Bryon; Liu, Zhuqing; Klapars, Artis; Bellomo Peraza, Ana Ines; Silverman, Steven M.; Mechanism-Based Solution to the ProTide Synthesis Problem: Selective Access to Sofosbuvir, Acelarin, and INX-08189; American Chemical Society; Organic Letters; 19; 9; 5-2017; 2218-2221
dc.identifier1523-7060
dc.identifierhttp://hdl.handle.net/11336/51170
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1885914
dc.description.abstractA general and efficient method for the synthesis of pronucleotide (ProTide) 5'-phosphoramidate monoesters is reported. This method consists of a highly stereoselective 5'-phosphorylation mediated by dimethylaluminum chloride to afford the desired target ProTides in excellent yields without employing 3'-protection strategies. The application of this methodology to the synthesis of a number of pharmaceutically relevant compounds currently marketed or under investigation in clinical research is demonstrated.
dc.languageeng
dc.publisherAmerican Chemical Society
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/acs.orglett.7b00469
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acs.orglett.7b00469
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectNUCLEOSIDE
dc.subjectPHOSPHORYLATION
dc.subjectREGIOSELECTIVE
dc.titleMechanism-Based Solution to the ProTide Synthesis Problem: Selective Access to Sofosbuvir, Acelarin, and INX-08189
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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