Artículos de revistas
New Mucoadhesive Polymeric Film for Ophthalmic Administration of Acetazolamide
Ahumada, Maria I.; Tartara, Luis Ignacio; Palma, Santiago Daniel; Llabot, Juan Manuel; Allemandi, Daniel Alberto; New Mucoadhesive Polymeric Film for Ophthalmic Administration of Acetazolamide; Bentham Science; Recent Patents on Drug Delivery & Formulation; 8; 3; 8-2014; 224-232
Tartara, Luis Ignacio
Palma, Santiago Daniel
Ahumada, Maria I.
Allemandi, Daniel Alberto
Llabot, Juan Manuel
This article reports the results concerning the design and manufacture of a novel polymeric film for ocular ad-ministration of acetazolamide (AZM), and a patent document presented to INPI- National Institute of Industrial/Intelectual Property. The system was designed using mucoadhesive polymers, such as carbomer (CB974P) and sodium car-boxymethylcellulose (NaCMC), combined with the poloxamer (POL407) which behaves as a swelling modulator, surfac-tant and slightly plasticizer. The maximum amount of AZM to be incorporated without loss of homogeneity or precipita-tion of the drug, was 0.04 mg AZM/mg of the film. The addition of a polymeric coating based on Eudragit RSPO (cati-onic permeable polymethacrylate polymer) allowed optimizing drug release. The coating in a proportion of 10% (deter-mined as percentage of total weight of the film) seemed to be the most adequate, since 80% of controlled drug release was achieved along 240 minutes. This coating membrane did not affect the mucoadhesive properties of the swellable poly-mers. Thus, the system obtained, showed good efficiency and the intra ocular pressure (IOP) decreased according to the results derived from in vivo studies performed on normotensive rabbits. Finally, irritation scored studies demonstrated that these systems were not irritant for rabbit ́s ocular mucosa.