dc.creatorKuminek, Gislaine
dc.creatorRauber, Gabriela Schneider
dc.creatorRiekes, Manoela Klüppel
dc.creatorCampos, Carlos Eduardo Maduro de
dc.creatorMonti, Gustavo Alberto
dc.creatorBortoluzzi, Adailton João
dc.creatorCuffini, Silvia Lucia
dc.creatorCardoso, Simone Goncalves
dc.date.accessioned2017-10-03T17:41:24Z
dc.date.accessioned2018-11-06T14:18:23Z
dc.date.available2017-10-03T17:41:24Z
dc.date.available2018-11-06T14:18:23Z
dc.date.created2017-10-03T17:41:24Z
dc.date.issued2013-02
dc.identifierKuminek, Gislaine; Rauber, Gabriela Schneider; Riekes, Manoela Klüppel; Campos, Carlos Eduardo Maduro de; Monti, Gustavo Alberto; et al.; Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 78-79; 2-2013; 105-111
dc.identifier0731-7085
dc.identifierhttp://hdl.handle.net/11336/25784
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1885024
dc.description.abstractTerbinafine hydrochloride (TH), a poorly water soluble antifungal agent, was characterized by solid state techniques including differential scanning calorimetry, thermogravimetry, X-ray powder diffraction, optical and electron microscopies, Fourier transform infrared, Raman and solid-state nuclear magnetic resonance spectroscopies and intrinsic dissolution rate (IDR). A colorless single crystal of TH was grown from an ethanol:water solution and its crystalline structure was determined through X-ray single crystal diffraction. Also, a new crystal habit of TH was obtained through the slow solvent evaporation technique revealing a needle-like shape. A comparison between the IDR results for the TH raw material and TH needle-like crystal revealed lower values for the new crystal habit, which can be attributed to the preferential orientation of the crystals in the compressed disks.
dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jpba.2013.02.001
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0731708513000587
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectTERBINAFINE HYDROCHLORIDE
dc.subjectSINGLE CRYSTAL STRUCTURE
dc.subjectSOLID STATE CHARACTERIZATION
dc.subjectINTRINSIC DISOLUTION RATE
dc.titleSingle crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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