dc.creator | Kuminek, Gislaine | |
dc.creator | Rauber, Gabriela Schneider | |
dc.creator | Riekes, Manoela Klüppel | |
dc.creator | Campos, Carlos Eduardo Maduro de | |
dc.creator | Monti, Gustavo Alberto | |
dc.creator | Bortoluzzi, Adailton João | |
dc.creator | Cuffini, Silvia Lucia | |
dc.creator | Cardoso, Simone Goncalves | |
dc.date.accessioned | 2017-10-03T17:41:24Z | |
dc.date.accessioned | 2018-11-06T14:18:23Z | |
dc.date.available | 2017-10-03T17:41:24Z | |
dc.date.available | 2018-11-06T14:18:23Z | |
dc.date.created | 2017-10-03T17:41:24Z | |
dc.date.issued | 2013-02 | |
dc.identifier | Kuminek, Gislaine; Rauber, Gabriela Schneider; Riekes, Manoela Klüppel; Campos, Carlos Eduardo Maduro de; Monti, Gustavo Alberto; et al.; Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 78-79; 2-2013; 105-111 | |
dc.identifier | 0731-7085 | |
dc.identifier | http://hdl.handle.net/11336/25784 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1885024 | |
dc.description.abstract | Terbinafine hydrochloride (TH), a poorly water soluble antifungal agent, was characterized by solid state techniques including differential scanning calorimetry, thermogravimetry, X-ray powder diffraction, optical and electron microscopies, Fourier transform infrared, Raman and solid-state nuclear magnetic resonance spectroscopies and intrinsic dissolution rate (IDR). A colorless single crystal of TH was grown from an ethanol:water solution and its crystalline structure was determined through X-ray single crystal diffraction. Also, a new crystal habit of TH was obtained through the slow solvent evaporation technique revealing a needle-like shape. A comparison between the IDR results for the TH raw material and TH needle-like crystal revealed lower values for the new crystal habit, which can be attributed to the preferential orientation of the crystals in the compressed disks. | |
dc.language | eng | |
dc.publisher | Elsevier Science | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jpba.2013.02.001 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0731708513000587 | |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | TERBINAFINE HYDROCHLORIDE | |
dc.subject | SINGLE CRYSTAL STRUCTURE | |
dc.subject | SOLID STATE CHARACTERIZATION | |
dc.subject | INTRINSIC DISOLUTION RATE | |
dc.title | Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |