dc.creatorCabrera, Maia Diana Eliana
dc.creatorEcheverría, Emiliana Beatriz
dc.creatorRemes Lenicov, Federico
dc.creatorCardama, Georgina Alexandra
dc.creatorGonzález, Nazareno
dc.creatorDavio, Carlos Alberto
dc.creatorFernandez, Natalia Cristina
dc.creatorLorenzano Menna, Pablo
dc.date.accessioned2018-06-04T14:59:00Z
dc.date.available2018-06-04T14:59:00Z
dc.date.created2018-06-04T14:59:00Z
dc.date.issued2017-10
dc.identifierCabrera, Maia Diana Eliana; Echeverría, Emiliana Beatriz; Remes Lenicov, Federico; Cardama, Georgina Alexandra; González, Nazareno; et al.; Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines; Impact Journals LLC; Oncotarget; 8; 58; 10-2017; 98509-98523
dc.identifier1949-2553
dc.identifierhttp://hdl.handle.net/11336/47116
dc.identifierCONICET Digital
dc.identifierCONICET
dc.description.abstractRac1 GTPase has long been recognized as a critical regulatory protein in different cellular and molecular processes involved in cancer progression, including acute myeloid leukemia. Here we show the antitumoral activity of ZINC69391 and 1A-116, two chemically-related Rac1 pharmacological inhibitors, on a panel of four leukemic cell lines representing different levels of maturation. Importantly, we show that the main mechanism involved in the antitumoral effect triggered by the Rac1 inhibitors comprises the induction of the mitochondrial or intrinsic apoptotic pathway. Interestingly, Rac1 inhibition selectively induced apoptosis on patientderived leukemia cells but not on normal mononuclear cells. These results show the potential therapeutic benefits of targeting Rac1 pathway in hematopoietic malignancies.
dc.languageeng
dc.publisherImpact Journals LLC
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.18632/oncotarget.21533
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=21533&path[]=68418
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject1A-116
dc.subjectACUTE MYELOID LEUKEMIA
dc.subjectAPOPTOSIS
dc.subjectRAC1
dc.subjectZINC69391
dc.titlePharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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