dc.creator | Gamberale, Romina | |
dc.creator | Geffner, Jorge Raúl | |
dc.creator | Giordano, Mirta Nilda | |
dc.date.accessioned | 2018-08-13T15:04:21Z | |
dc.date.accessioned | 2018-11-06T13:58:37Z | |
dc.date.available | 2018-08-13T15:04:21Z | |
dc.date.available | 2018-11-06T13:58:37Z | |
dc.date.created | 2018-08-13T15:04:21Z | |
dc.date.issued | 2002-02 | |
dc.identifier | Gamberale, Romina; Geffner, Jorge Raúl; Giordano, Mirta Nilda; Immune complexes and apoptosis in B-cell chronic lymphocytic leukemia; Taylor & Francis; Leukemia and Lymphoma; 43; 2; 2-2002; 251-255 | |
dc.identifier | 1042-8194 | |
dc.identifier | http://hdl.handle.net/11336/55114 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1881317 | |
dc.description.abstract | The progressive accumulation of B-cell chronic lymphocytic leukemia (B-CLL) cells in vivo is attributed to resistance to apoptosis, although this can be modulated in vitro by a variety of cellular and humoral factors (cell-cell, cell-matrix interactions, cytokines). We have previously reported that IgG immune complexes (IC) delay B-CLL cell apoptosis through a paracrine mechanism, which depends on monocytes and NK cells. On the other hand, despite the fact that IC effectively bind to type II FcγRs expressed on B-CLL cells, they are unable to deliver transmembrane signals. We speculate that this lack of responsiveness of resting B-CLL cells to IC could be overcome by activation. The analysis of this possibility would be relevant since the presence of circulating IC is a common feature in B-CLL patients. | |
dc.language | eng | |
dc.publisher | Taylor & Francis | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/10428190290006008 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/10428190290006008 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | APOPTOSIS | |
dc.subject | B-CLL | |
dc.subject | FCΓRS | |
dc.subject | IMMUNE COMPLEXES | |
dc.title | Immune complexes and apoptosis in B-cell chronic lymphocytic leukemia | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |