dc.creatorSuárez Esquivel, Marcela
dc.creatorRuiz Villalobos, Nazareth
dc.creatorCastillo Zeledón, Amanda
dc.creatorJiménez Rojas, César
dc.creatorRoop II, R. Martin
dc.creatorComerci, Diego José
dc.creatorBarquero Calvo, Elías
dc.creatorChacón Díaz, Carlos
dc.creatorCaswell, Clayton C.
dc.creatorBaker, Kate S.
dc.creatorChaves Olarte, Esteban
dc.creatorThomson, Nicholas R.
dc.creatorMoreno, Edgardo
dc.creatorLetesson, Jean J.
dc.creatorDe Bolle, Xavier
dc.creatorGuzmán Verri, Caterina
dc.date.accessioned2018-08-09T21:50:50Z
dc.date.accessioned2018-11-06T13:55:27Z
dc.date.available2018-08-09T21:50:50Z
dc.date.available2018-11-06T13:55:27Z
dc.date.created2018-08-09T21:50:50Z
dc.date.issued2016-09
dc.identifierSuárez Esquivel, Marcela; Ruiz Villalobos, Nazareth; Castillo Zeledón, Amanda; Jiménez Rojas, César; Roop II, R. Martin; et al.; Brucella abortus strain 2308 Wisconsin genome: Importance of the definition of reference strains; Frontiers Research Foundation; Frontiers in Microbiology; 7; 9-2016; 1-7
dc.identifier1664-302X
dc.identifierhttp://hdl.handle.net/11336/54913
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1880674
dc.description.abstractBrucellosis is a bacterial infectious disease affecting a wide range of mammals and a neglected zoonosis caused by species of the genetically homogenous genus Brucella. As in most studies on bacterial diseases, research in brucellosis is carried out by using reference strains as canonical models to understand the mechanisms underlying host pathogen interactions. We performed whole genome sequencing analysis of the reference strain B. abortus 2308 routinely used in our laboratory, including manual curated annotation accessible as an editable version through a link at https://en.wikipedia.org/wiki/Brucella#Genomics. Comparison of this genome with two publically available 2308 genomes showed significant differences, particularly indels related to insertional elements, suggesting variability related to the transposition of these elements within the same strain. Considering the outcome of high resolution genomic techniques in the bacteriology field, the conventional concept of strain definition needs to be revised.
dc.languageeng
dc.publisherFrontiers Research Foundation
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fmicb.2016.01557
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmicb.2016.01557/full
dc.rightshttps://creativecommons.org/licenses/by/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBRUCELLA BRUCELLA ABORTUS
dc.subjectREFERENCE GENOME
dc.subjectREFERENCE STRAIN
dc.subjectWGS
dc.titleBrucella abortus strain 2308 Wisconsin genome: Importance of the definition of reference strains
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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