dc.creatorGalaka, Tamila Pavlivna
dc.creatorFerrer, Mariana
dc.creatorStorey, Melissa
dc.creatorLi, Catherine
dc.creatorChao, Maria Noelia
dc.creatorSzajnman, Sergio Hernan
dc.creatorDocampo, Roberto
dc.creatorMoreno, Silvia N. J.
dc.creatorRodriguez, Juan Bautista
dc.date.accessioned2018-09-19T15:46:47Z
dc.date.accessioned2018-11-06T13:52:15Z
dc.date.available2018-09-19T15:46:47Z
dc.date.available2018-11-06T13:52:15Z
dc.date.created2018-09-19T15:46:47Z
dc.date.issued2017-01
dc.identifierGalaka, Tamila Pavlivna; Ferrer, Mariana; Storey, Melissa; Li, Catherine; Chao, Maria Noelia; et al.; Antiparasitic activity of sulfur- and fluorine-containing bisphosphonates against trypanosomatids and apicomplexan parasites; Molecular Diversity Preservation International; Molecules; 22; 1; 1-2017; 1-22
dc.identifier1420-3049
dc.identifierhttp://hdl.handle.net/11336/60217
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1880306
dc.description.abstractBased on crystallographic data of the complexes 2-alkyl(amino)ethyl-1,1-bisphosphonates-Trypanosoma cruzi farnesyl diphosphate synthase, some linear 1,1-bisphosphonic acids and other closely related derivatives were designed, synthesized and biologically evaluated against T. cruzi, the responsible agent of Chagas disease and against Toxoplasma gondii, the etiologic agent of toxoplasmosis and also towards the target enzymes farnesyl pyrophosphate synthase of T. cruzi (TcFPPS) and T gondii (TgFPPS), respectively. The isoprenoid-containing 1,1-bisphosphonates exhibited modest antiparasitic activity, whereas the linear α-fluoro-2-alkyl(amino)ethyl-1,1-bisphosphonates were unexpectedly devoid of antiparasitic activity. In spite of not presenting efficient antiparasitic activity, these data turned out to be very important to establish a structural activity relationship.
dc.languageeng
dc.publisherMolecular Diversity Preservation International
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.3390/molecules22010082
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1420-3049/22/1/82
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectANTIPARASITIC AGENTS
dc.subjectBISPHOSPHONATES
dc.subjectCHAGAS DISEASE
dc.subjectFARNESYL DIPHOSPHATE SYNTHASE
dc.subjectTOXOPLASMA GONDII
dc.subjectTOXOPLASMOSIS
dc.subjectTRYPANOSOMA CRUZI
dc.titleAntiparasitic activity of sulfur- and fluorine-containing bisphosphonates against trypanosomatids and apicomplexan parasites
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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