dc.creator | Galaka, Tamila Pavlivna | |
dc.creator | Ferrer, Mariana | |
dc.creator | Storey, Melissa | |
dc.creator | Li, Catherine | |
dc.creator | Chao, Maria Noelia | |
dc.creator | Szajnman, Sergio Hernan | |
dc.creator | Docampo, Roberto | |
dc.creator | Moreno, Silvia N. J. | |
dc.creator | Rodriguez, Juan Bautista | |
dc.date.accessioned | 2018-09-19T15:46:47Z | |
dc.date.accessioned | 2018-11-06T13:52:15Z | |
dc.date.available | 2018-09-19T15:46:47Z | |
dc.date.available | 2018-11-06T13:52:15Z | |
dc.date.created | 2018-09-19T15:46:47Z | |
dc.date.issued | 2017-01 | |
dc.identifier | Galaka, Tamila Pavlivna; Ferrer, Mariana; Storey, Melissa; Li, Catherine; Chao, Maria Noelia; et al.; Antiparasitic activity of sulfur- and fluorine-containing bisphosphonates against trypanosomatids and apicomplexan parasites; Molecular Diversity Preservation International; Molecules; 22; 1; 1-2017; 1-22 | |
dc.identifier | 1420-3049 | |
dc.identifier | http://hdl.handle.net/11336/60217 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1880306 | |
dc.description.abstract | Based on crystallographic data of the complexes 2-alkyl(amino)ethyl-1,1-bisphosphonates-Trypanosoma cruzi farnesyl diphosphate synthase, some linear 1,1-bisphosphonic acids and other closely related derivatives were designed, synthesized and biologically evaluated against T. cruzi, the responsible agent of Chagas disease and against Toxoplasma gondii, the etiologic agent of toxoplasmosis and also towards the target enzymes farnesyl pyrophosphate synthase of T. cruzi (TcFPPS) and T gondii (TgFPPS), respectively. The isoprenoid-containing 1,1-bisphosphonates exhibited modest antiparasitic activity, whereas the linear α-fluoro-2-alkyl(amino)ethyl-1,1-bisphosphonates were unexpectedly devoid of antiparasitic activity. In spite of not presenting efficient antiparasitic activity, these data turned out to be very important to establish a structural activity relationship. | |
dc.language | eng | |
dc.publisher | Molecular Diversity Preservation International | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.3390/molecules22010082 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1420-3049/22/1/82 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | ANTIPARASITIC AGENTS | |
dc.subject | BISPHOSPHONATES | |
dc.subject | CHAGAS DISEASE | |
dc.subject | FARNESYL DIPHOSPHATE SYNTHASE | |
dc.subject | TOXOPLASMA GONDII | |
dc.subject | TOXOPLASMOSIS | |
dc.subject | TRYPANOSOMA CRUZI | |
dc.title | Antiparasitic activity of sulfur- and fluorine-containing bisphosphonates against trypanosomatids and apicomplexan parasites | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |