dc.creatorPampena, María Betina
dc.creatorLevy, Estrella Mariel
dc.date.accessioned2018-07-04T18:42:53Z
dc.date.accessioned2018-11-06T13:48:10Z
dc.date.available2018-07-04T18:42:53Z
dc.date.available2018-11-06T13:48:10Z
dc.date.created2018-07-04T18:42:53Z
dc.date.issued2015-01
dc.identifierPampena, María Betina; Levy, Estrella Mariel; Natural killer cells as helper cells in dendritic cell cancer vaccines; Frontiers Research Foundation; Frontiers in Immunology; 6; JAN; 1-2015; 1-8
dc.identifier1664-3224
dc.identifierhttp://hdl.handle.net/11336/51225
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1879575
dc.description.abstractVaccine-based cancer immunotherapy has generated highly variable clinical results due to differing methods of vaccine preparation and variation in patient populations among other lesser factors. Moreover, these clinical responses do not necessarily correspond with the induction of tumor-specific cytotoxic lymphocytes. Here, we review the participation of natural killer (NK) cells as alternative immune components that could cooperate in successful vaccination treatment. NK cells have been described as helper cells in dendritic cell-based cancer vaccines, but the role in other kinds of vaccination strategies (whole cells, peptide, or DNA-based vaccines) is poorly understood. In this article, we address the following issues regarding the role of NK cells in cancer vaccines: NK cell anti-tumor action sites, and the loci of NK cell interaction with other immune cells; descriptions of new data on the memory characteristics of NK cells described in infectious diseases; and finally phenotypical and functional changes after vaccination measured by immunomonitoring in preclinical and clinical settings.
dc.languageeng
dc.publisherFrontiers Research Foundation
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fimmu.2015.00013
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2015.00013/full
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCANCER VACCINES
dc.subjectDENDRITIC CELLS VACCINES
dc.subjectIMMUNOMONITORING
dc.subjectNATURAL KILLER CELLS
dc.subjectNK CELLS-DENDRITIC CELLS CROSSTALK
dc.titleNatural killer cells as helper cells in dendritic cell cancer vaccines
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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