Optimization of diarylazines as anti-HIV agents with dramatically

dc.creatorBollini, Mariela
dc.creatorCisneros, José A.
dc.creatorSpasov, Krasimir A.
dc.creatorAnderson, Karen S.
dc.creatorJorgensen, William L.
dc.date.accessioned2017-09-21T21:16:33Z
dc.date.accessioned2018-11-06T13:46:28Z
dc.date.available2017-09-21T21:16:33Z
dc.date.available2018-11-06T13:46:28Z
dc.date.created2017-09-21T21:16:33Z
dc.date.issued2013-07
dc.identifierBollini, Mariela; Cisneros, José A.; Spasov, Krasimir A.; Anderson, Karen S.; Jorgensen, William L.; Optimization of diarylazines as anti-HIV agents with dramatically; Elsevier; Bioorganic & Medicinal Chemistry Letters; 23; 18; 7-2013; 5213-5216
dc.identifier0960-894X
dc.identifierhttp://hdl.handle.net/11336/24881
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1879184
dc.description.abstractNon-nucleoside inhibitors of HIV-1 reverse transcriptase are reported that have ca. 100-fold greater solubility than the structurally related drugs etravirine and rilpivirine, while retaining high anti-viral activity. The solubility enhancements come from strategic placement of a morpholinylalkoxy substituent in the entrance channel of the NNRTI binding site. Compound 4d shows low-nanomolar activity similar to etravirine towards wild-type HIV-1 and key viral variants.
dc.languageeng
dc.publisherElsevier
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bmcl.2013.06.091
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0960894X1300824X
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759246/
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnti-HIV agent
dc.subjectNNRTI
dc.subjectDrug solubility
dc.titleOptimization of diarylazines as anti-HIV agents with dramatically
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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