Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells

dc.creatorHosoya, Soichi
dc.creatorVillena, Julio Cesar
dc.creatorShimazu, Tomoyuki
dc.creatorTohno, Masanori
dc.creatorFujie, Hitomi
dc.creatorChiba, Eriko
dc.creatorShimosato, Takeshi
dc.creatorAso, Hisashi
dc.creatorSuda, Yoshihito
dc.creatorKawai, Yasushi
dc.creatorSaito, Tadao
dc.creatorAlvarez, Gladis Susana
dc.creatorIkegami, Shuji
dc.creatorItoh, Hiroyuki
dc.creatorKitazawa, Haruki
dc.date.accessioned2018-08-09T17:02:19Z
dc.date.available2018-08-09T17:02:19Z
dc.date.created2018-08-09T17:02:19Z
dc.date.issued2011-11-03
dc.identifierHosoya, Soichi; Villena, Julio Cesar; Shimazu, Tomoyuki; Tohno, Masanori; Fujie, Hitomi; et al.; Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells; BioMed Central; Veterinary Research; 42; 1; 3-11-2011; 1-13; 111
dc.identifier0928-4249
dc.identifierhttp://hdl.handle.net/11336/54793
dc.identifier1297-9716
dc.identifierCONICET Digital
dc.identifierCONICET
dc.description.abstractThis study analyzed the functional expression of TLR3 in various gastrointestinal tissues from adult swine and shows that TLR3 is expressed preferentially in intestinal epithelial cells (IEC), CD172a +CD11R1 high and CD4 + cells from ileal Peyer's patches. We characterized the inflammatory immune response triggered by TLR3 activation in a clonal porcine intestinal epitheliocyte cell line (PIE cells) and in PIE-immune cell co-cultures, and demonstrated that these systems are valuable tools to study in vitro the immune response triggered by TLR3 on IEC and the interaction between IEC and immune cells. In addition, we selected an immunobiotic lactic acid bacteria strain, Lactobacillus casei MEP221106, able to beneficially regulate the anti-viral immune response triggered by poly(I:C) stimulation in PIE cells. Moreover, we deepened our understanding of the possible mechanisms of immunobiotic action by demonstrating that L. casei MEP221106 modulates the interaction between IEC and immune cells during the generation of a TLR3-mediated immune response.
dc.languageeng
dc.publisherBioMed Central
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/1297-9716-42-111
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://veterinaryresearch.biomedcentral.com/articles/10.1186/1297-9716-42-111
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPorcine Intestinal Epithelial Cells
dc.subjectInflammatory Response
dc.subjectImmunobiotics
dc.subjectPoly(I:C)
dc.titleImmunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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