dc.creator | Colomer, Juan Pablo | |
dc.creator | Fernández de Toro, Beatriz | |
dc.creator | Cañada, F. Javier | |
dc.creator | Corzana, Francisco | |
dc.creator | Jiménez Barbero, Jesús | |
dc.creator | Canales, Angeles | |
dc.creator | Varela, Oscar Jose | |
dc.date.accessioned | 2018-09-07T18:02:06Z | |
dc.date.accessioned | 2018-11-06T13:30:20Z | |
dc.date.available | 2018-09-07T18:02:06Z | |
dc.date.available | 2018-11-06T13:30:20Z | |
dc.date.created | 2018-09-07T18:02:06Z | |
dc.date.issued | 2016-09 | |
dc.identifier | Colomer, Juan Pablo; Fernández de Toro, Beatriz; Cañada, F. Javier; Corzana, Francisco; Jiménez Barbero, Jesús; et al.; Diastereomeric Glycosyl Sulfoxides Display Different Recognition Features versus E. coli β-Galactosidase; Wiley VCH Verlag; European Journal of Organic Chemistry; 2016; 30; 9-2016; 5117-5122 | |
dc.identifier | 1434-193X | |
dc.identifier | http://hdl.handle.net/11336/58756 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1876093 | |
dc.description.abstract | The conformational analysis of the (S) and (R) diastereoisomers of benzyl 3-deoxy-4S-(β-d-galactopyranosyl)-4-thio-β-d-threo-pentopyranoside S-oxide (1S and 1R, respectively) has been performed by using NMR spectroscopy assisted by molecular modelling methods. The results point out that sulfoxide 1S and 1R display rather different conformational behaviors, 1S being significantly more flexible than 1R. Both sulfoxides have shown to be competitive inhibitors of the β-galactosidase from E. coli, although with different potencies. The key structural features of the molecular recognition process have been characterized. | |
dc.language | eng | |
dc.publisher | Wiley VCH Verlag | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1002/ejoc.201600835 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.201600835 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | CONFORMATION ANALYSIS | |
dc.subject | GLYCOMIMETICS | |
dc.subject | GLYCOSIDASES | |
dc.subject | MOLECULAR RECOGNITION | |
dc.title | Diastereomeric Glycosyl Sulfoxides Display Different Recognition Features versus E. coli β-Galactosidase | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |