Molecular characterization of a clinical Haemophilus parainfluenzae isolate with cefotaxime resistance and decreased susceptibility to fluoroquinolones

dc.creatorFaccone, Diego Francisco
dc.creatorLopez Ruitti, Paula
dc.creatorVazquez, Miryam
dc.creatorGuerriero, Leonor
dc.creatorLucero, Celeste
dc.creatorGagetti, Paula Silvana
dc.creatorCeriana, Paola
dc.creatorCorso, Alejandra
dc.date.accessioned2018-05-31T14:51:08Z
dc.date.available2018-05-31T14:51:08Z
dc.date.created2018-05-31T14:51:08Z
dc.date.issued2016-10
dc.identifierFaccone, Diego Francisco; Lopez Ruitti, Paula; Vazquez, Miryam; Guerriero, Leonor; Lucero, Celeste; et al.; Molecular characterization of a clinical Haemophilus parainfluenzae isolate with cefotaxime resistance and decreased susceptibility to fluoroquinolones; Elsevier Science; Infection, Genetics and Evolution; 44; 10-2016; 507-509
dc.identifier1567-1348
dc.identifierhttp://hdl.handle.net/11336/46787
dc.identifierCONICET Digital
dc.identifierCONICET
dc.description.abstractWe report an H. parainfluenzae clinical isolate resistant to cefotaxime and with decreased susceptibility to ciprofloxacinrecovered from a patient with cystic fibrosis. The isolate had elevated MICs of ampicillin (256 mg/L), amoxicillin-clavulanate(8 mg/L), cefuroxime (8 mg/L) and cefotaxime (4 mg/L), and showed a β-lactamase-producing amoxicillin-clavulanicacid-resistant (BLPACR) phenotype. A blaTEM-1 plus five amino acid substitutions in the PBP3 were found:Ser385Thr, Val511Ala, Ile519Val, Asn526Lys and Asp551Leu. MIC of ciprofloxacin was 0.5 mg/L, and substitutions ingyrA (Ser84Tyr) and parC (Ser84Phe) genes were detected.
dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.meegid.2016.08.003
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1567134816303409
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHaemophilus
dc.subjectCefotaxime
dc.subjectFluoroquinolone
dc.subjectPbp3
dc.titleMolecular characterization of a clinical Haemophilus parainfluenzae isolate with cefotaxime resistance and decreased susceptibility to fluoroquinolones
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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