dc.creator | Hoyos, Hernán Carlos | |
dc.creator | Marder, Nora Mariel | |
dc.creator | Ulrich, R. | |
dc.creator | Gudi, V. | |
dc.creator | Stangel, M. | |
dc.creator | Rabinovich, Gabriel Adrián | |
dc.creator | Pasquini, Laura Andrea | |
dc.creator | Pasquini, Juana Maria | |
dc.date.accessioned | 2017-09-19T15:42:52Z | |
dc.date.accessioned | 2018-11-06T13:16:40Z | |
dc.date.available | 2017-09-19T15:42:52Z | |
dc.date.available | 2018-11-06T13:16:40Z | |
dc.date.created | 2017-09-19T15:42:52Z | |
dc.date.issued | 2016-10 | |
dc.identifier | Hoyos, Hernán Carlos; Marder, Nora Mariel; Ulrich, R.; Gudi, V.; Stangel, M.; et al.; The role of galectin-3: From oligodendroglial differentiation and myelination to demyelination and remyelination processes in a cuprizone-induced demyelination model; Springer International Publishing; Advances In Experimental Medicine And Biology.; 949; 10-2016; 311-332 | |
dc.identifier | 978-3-319-40762-3 | |
dc.identifier | 0065-2598 | |
dc.identifier | http://hdl.handle.net/11336/24576 | |
dc.identifier | 2214-8019 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1873735 | |
dc.description.abstract | The aim of this work was to combine our previously published results with our new data to show how galectin-3 (Gal-3) controls myelin integrity and function, promotes oligodendroglial cell differentiation, and regulates microglial responses to limit cuprizone- (CPZ)-induced demyelination and foster remyelination. In this study, 8-week-old Gal-3-deficient (Lgals3−/−) and wild type (WT) mice were fed a diet containing 0.2 % CPZ w/w for 6 weeks, after which CPZ was withdrawn in order to allow remyelination. Our results show that remyelination was less efficient in Lgals3−/− than in WT mice. Electron microscopic images from remyelinated sections in Lgals3−/− mice revealed collapsed axons with a defective myelin wrap, while remyelinated WT mice had normal axons without relevant myelin wrap disruption. MMP-3 expression increased during remyelination in WT but not in Lgals3−/− mice. The number of CD45+, TNFa+ and TREM-2b+ cells decreased only in WT mice only, with no alterations in Lgals3−/− mice during demyelination and remyelination. Therefore, Gal-3 influences remyelination by mechanisms involving the tuning of microglial cells, modulation of MMP activity, and changes in myelin architecture. | |
dc.language | eng | |
dc.publisher | Springer International Publishing | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/978-3-319-40764-7_15 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/chapter/10.1007%2F978-3-319-40764-7_15 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | GALECTIN-3 | |
dc.subject | REMYELINATION | |
dc.subject | MMPs | |
dc.subject | MICROGLIA | |
dc.subject | OLIGODENDROCYTES | |
dc.title | The role of galectin-3: From oligodendroglial differentiation and myelination to demyelination and remyelination processes in a cuprizone-induced demyelination model | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |