info:eu-repo/semantics/article
α-Lipoic acid protects kidney from oxidative stress and mitochondrial dysfunction associated to inflammatory conditions
Fecha
2014-09Registro en:
Cimolai, María Cecilia; Vanasco, Virginia; Marchini, Timoteo Oscar; Magnani, Natalia Daniela; Evelson, Pablo Andrés; et al.; α-Lipoic acid protects kidney from oxidative stress and mitochondrial dysfunction associated to inflammatory conditions; Royal Society of Chemistry; Food and Function; 5; 12; 9-2014; 3143-3150
2042-6496
2042-650X
CONICET Digital
CONICET
Autor
Cimolai, María Cecilia
Vanasco, Virginia
Marchini, Timoteo Oscar
Magnani, Natalia Daniela
Evelson, Pablo Andrés
Alvarez, Silvia
Resumen
An adequate redox status is important for maintaining mitochondrial function in inflammatory conditions. The aim of this work was to evaluate the effects of α-lipoic acid (LA) in kidney oxidative metabolism and mitochondrial function in lipopolysaccharide (LPS) treated rats. Sprague-Dawley rats (female, 45 ± 5 days old) were treated with LPS (10 mg/kg) and/or LA (100 mg/kg). LA prevented the 1.2 fold increase in NO production, decreased (30-40%) mitochondrial complex I-III and IV activities, and decreased (26%) membrane potential and cardiolipin oxidation (76%) observed in LPS-treated animals. No differences were observed in mitochondrial O2 consumption, mitochondrial complex II-III activity, and ATP production when LPS group was compared to LA+LPS group. Based on the improvement of the mitochondrial function, decreased production of mitochondrial NO and restoration of cardiolipin levels, this work provides new evidence that α-lipoic acid protects kidney from oxidative stress and mitochondrial dysfunction.