dc.creatorMarin, Maia Solange
dc.creatorLeunda, Maria Rosa
dc.creatorVerna, Andrea Elizabeth
dc.creatorMorán, Pedro Edgardo
dc.creatorOdeón, Anselmo Carlos
dc.creatorPerez, Sandra
dc.date.accessioned2018-10-12T17:24:29Z
dc.date.accessioned2018-11-06T12:56:46Z
dc.date.available2018-10-12T17:24:29Z
dc.date.available2018-11-06T12:56:46Z
dc.date.created2018-10-12T17:24:29Z
dc.date.issued2016-03
dc.identifierMarin, Maia Solange; Leunda, Maria Rosa; Verna, Andrea Elizabeth; Morán, Pedro Edgardo; Odeón, Anselmo Carlos; et al.; Distribution of bovine herpesvirus type 1 in the nervous system of experimentally infected calves; Elsevier; The Veterinary Journal; 209; 3-2016; 82-86
dc.identifier1090-0233
dc.identifierhttp://hdl.handle.net/11336/62319
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1871487
dc.description.abstractBovine herpesvirus type 1 (BoHV-1) is responsible for respiratory and genital disease in cattle. BoHV-1 encephalitis is only occasionally reported. However, several cases of neurological disease have been recently attributed to BoHV-1. In this study, the distribution and pathological alterations caused by two BoHV-1 strains in the nervous system of experimentally infected calves during acute infection and reactivation are described. Calves were inoculated intranasally with BoHV-1 Los Angeles (BoHV-1.LA) or Cooper (BoHV-1.Cooper) strains. Acutely infected calves were euthanased at 6 days (BoHV-1.Cooper, n = 2) and 7 days post-inoculation (BoHV-1.LA, n = 2). Latently infected calves that were given dexamethasone to induce reactivation were euthanased at 2 days (BoHV-1.Cooper, n = 2) or 5 days (BoHV-1.LA, n = 2) after dexamethasone administration. Both BoHV-1 strains were isolated from the brains of acutely infected calves. Distribution of viral DNA in the neural tissues was similar for both strains. During reactivation, neither BoHV-1.LA nor BoHV-1.Cooper was isolated from any brain section or trigeminal ganglia in infected calves. Macroscopic lesions were not evident in any group. In BoHV-1.LA infected calves, microscopic lesions were found in the brain but not in the trigeminal ganglia. Microscopic lesions in the brain of BoHV-1.Cooper infected calves were not as evident as in BoHV-1.LA infected animals. However, mononuclear infiltrates and neuronophagia were present in trigeminal ganglia. The results of this study demonstrated that respiratory BoHV-1 strains are able to replicate and disseminate within the bovine nervous tissue and provide evidence of the neuroinvasiveness of BoHV-1 strains.
dc.languageeng
dc.publisherElsevier
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1090023315004438
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.tvjl.2015.10.034
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBOVINE HERPESVIRUS TYPE 1
dc.subjectENCEPHALITIS
dc.subjectMICROSCOPIC LESIONS
dc.subjectNEUROINVASIVENESS
dc.titleDistribution of bovine herpesvirus type 1 in the nervous system of experimentally infected calves
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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