dc.creator | Marin, Maia Solange | |
dc.creator | Leunda, Maria Rosa | |
dc.creator | Verna, Andrea Elizabeth | |
dc.creator | Morán, Pedro Edgardo | |
dc.creator | Odeón, Anselmo Carlos | |
dc.creator | Perez, Sandra | |
dc.date.accessioned | 2018-10-12T17:24:29Z | |
dc.date.accessioned | 2018-11-06T12:56:46Z | |
dc.date.available | 2018-10-12T17:24:29Z | |
dc.date.available | 2018-11-06T12:56:46Z | |
dc.date.created | 2018-10-12T17:24:29Z | |
dc.date.issued | 2016-03 | |
dc.identifier | Marin, Maia Solange; Leunda, Maria Rosa; Verna, Andrea Elizabeth; Morán, Pedro Edgardo; Odeón, Anselmo Carlos; et al.; Distribution of bovine herpesvirus type 1 in the nervous system of experimentally infected calves; Elsevier; The Veterinary Journal; 209; 3-2016; 82-86 | |
dc.identifier | 1090-0233 | |
dc.identifier | http://hdl.handle.net/11336/62319 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1871487 | |
dc.description.abstract | Bovine herpesvirus type 1 (BoHV-1) is responsible for respiratory and genital disease in cattle. BoHV-1 encephalitis is only occasionally reported. However, several cases of neurological disease have been recently attributed to BoHV-1. In this study, the distribution and pathological alterations caused by two BoHV-1 strains in the nervous system of experimentally infected calves during acute infection and reactivation are described. Calves were inoculated intranasally with BoHV-1 Los Angeles (BoHV-1.LA) or Cooper (BoHV-1.Cooper) strains. Acutely infected calves were euthanased at 6 days (BoHV-1.Cooper, n = 2) and 7 days post-inoculation (BoHV-1.LA, n = 2). Latently infected calves that were given dexamethasone to induce reactivation were euthanased at 2 days (BoHV-1.Cooper, n = 2) or 5 days (BoHV-1.LA, n = 2) after dexamethasone administration. Both BoHV-1 strains were isolated from the brains of acutely infected calves. Distribution of viral DNA in the neural tissues was similar for both strains. During reactivation, neither BoHV-1.LA nor BoHV-1.Cooper was isolated from any brain section or trigeminal ganglia in infected calves. Macroscopic lesions were not evident in any group. In BoHV-1.LA infected calves, microscopic lesions were found in the brain but not in the trigeminal ganglia. Microscopic lesions in the brain of BoHV-1.Cooper infected calves were not as evident as in BoHV-1.LA infected animals. However, mononuclear infiltrates and neuronophagia were present in trigeminal ganglia. The results of this study demonstrated that respiratory BoHV-1 strains are able to replicate and disseminate within the bovine nervous tissue and provide evidence of the neuroinvasiveness of BoHV-1 strains. | |
dc.language | eng | |
dc.publisher | Elsevier | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1090023315004438 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.tvjl.2015.10.034 | |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | BOVINE HERPESVIRUS TYPE 1 | |
dc.subject | ENCEPHALITIS | |
dc.subject | MICROSCOPIC LESIONS | |
dc.subject | NEUROINVASIVENESS | |
dc.title | Distribution of bovine herpesvirus type 1 in the nervous system of experimentally infected calves | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |