info:eu-repo/semantics/article
Persistence of measles neutralizing antibody related to vaccine and natural infection adquired before HIV infection
Fecha
2013-10Registro en:
Isa, Maria Beatriz; Pavan, Jorge Victorio; Sicilia Don, Paola Ermelinda; Grutadauria, S.; Martinez, Laura Cecilia; et al.; Persistence of measles neutralizing antibody related to vaccine and natural infection adquired before HIV infection; Cambridge University Press; Epidemiology and Infection; 142; 8; 10-2013; 1708-1712
0950-2688
CONICET Digital
CONICET
Autor
Isa, Maria Beatriz
Pavan, Jorge Victorio
Sicilia Don, Paola Ermelinda
Grutadauria, S.
Martinez, Laura Cecilia
Giordano, Miguel Oscar
Masachessi, Gisela
Barril, Patricia Angelica
Nates, Silvia Viviana
Resumen
Little is known about long-lasting measles protective immunity when exposure to wild-type or vaccine measles virus precedes HIV infection. The results obtained suggest that measles immunity wanes and the lowest measles geometric mean titres (GMT) were significantly associated with measles vaccine-induced immunity in individuals that later developed HIV infection (86% prevalence, GMT 164 mIU/ml) compared to naturally induced immunity in HIV-infected adults (100% prevalence, GMT 340 mIU/ml, P= 0·0082) or non-HIV infected adults (100%, GMT 724 mIU/ml, P= 0·0001), and vaccine-induced immunity in non-HIV-infected adults (100%, GMT 347 mIU/ml, P= 0·017). The study was conducted in an area without wild-type virus circulation since 2000. The absence of virus circulating may alter the paradigm of lifelong immunity to measles virus after vaccination. As the proportion of HIV-infected individuals possessing only vaccine-induced immunity continues to grow, checking the status of measles immunity in this group is strongly recommended