dc.creator | Davicino, Roberto Carlos | |
dc.creator | Peralta, Ignacio Nahuel | |
dc.creator | Martino, Renzo Fabricio | |
dc.creator | Alonso, Rosario | |
dc.creator | Anesini, Claudia Alejandra | |
dc.date.accessioned | 2017-06-16T22:19:06Z | |
dc.date.accessioned | 2018-11-06T12:52:59Z | |
dc.date.available | 2017-06-16T22:19:06Z | |
dc.date.available | 2018-11-06T12:52:59Z | |
dc.date.created | 2017-06-16T22:19:06Z | |
dc.date.issued | 2015-08 | |
dc.identifier | Davicino, Roberto Carlos; Peralta, Ignacio Nahuel; Martino, Renzo Fabricio; Alonso, Rosario; Anesini, Claudia Alejandra; Preventive anti-inflammatory activity of an aqueous extract of larrea divaricata cav. and digestive and hematological toxicity; Society of Pharmaceutical Sciences & Research; International Journal of Pharmaceutical Sciences and Research; 6; 8; 8-2015; 1000-1010 | |
dc.identifier | 2320-5148 | |
dc.identifier | http://hdl.handle.net/11336/18394 | |
dc.identifier | 0975-8232 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1870795 | |
dc.description.abstract | Larrea divaricata Cav. commonly known as “jarilla hembra” is used in folklore medicine as anti-inflammatory. There was no scientific evidence justifying the medicinal use of the aqueous extract for inflammation diseases. Nowadays, there are two principal types of anti-inflammatory drugs: Steroidal anti-inflammatory drugs (corticosteroids) and non-steroidal anti-inflammatory drugs (NSAIDs), which exert gastrointestinal ulceration and bleeding. In this work the preventive anti-inflammatory activity of L. divaricata aqueous extract (AE) in C3H/He mice was determined by carrageenan- induced inflammation and ear edema tests, also its toxicity on gastric tissues and on blood cells was studied. The chromatographic profile showed: nordihydroguaiaretic acid (NDGA) as majority compound. AE exerted anti-inflammatory action without inducing gastric or blood cell toxicities. Also, it could modulate anti-inflammatory and pro-inflammatory cytokines. NDGA was not the compound responsible of the anti-inflammatory action. This work rescues the potentiality of AE as a gastric and blood cells innocuous anti-inflammatory agent and confirms its ethno- pharmacological uses. | |
dc.language | eng | |
dc.publisher | Society of Pharmaceutical Sciences & Research | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://ijpsr.com/bft-article/preventive-anti-inflammatory-activity-of-an-aqueous-extract-of-larrea-divaricata-cav-and-digestive-and-hematological-toxicity/?view=fulltext | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.13040/IJPSR.0975-8232.6(8).3215-23 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Larrea divaricata | |
dc.subject | Anti-inflammatory activity | |
dc.subject | Nordihydroguaiaretic acid | |
dc.subject | Aqueous extract | |
dc.title | Preventive anti-inflammatory activity of an aqueous extract of larrea divaricata cav. and digestive and hematological toxicity | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |