dc.creatorDavicino, Roberto Carlos
dc.creatorPeralta, Ignacio Nahuel
dc.creatorMartino, Renzo Fabricio
dc.creatorAlonso, Rosario
dc.creatorAnesini, Claudia Alejandra
dc.date.accessioned2017-06-16T22:19:06Z
dc.date.accessioned2018-11-06T12:52:59Z
dc.date.available2017-06-16T22:19:06Z
dc.date.available2018-11-06T12:52:59Z
dc.date.created2017-06-16T22:19:06Z
dc.date.issued2015-08
dc.identifierDavicino, Roberto Carlos; Peralta, Ignacio Nahuel; Martino, Renzo Fabricio; Alonso, Rosario; Anesini, Claudia Alejandra; Preventive anti-inflammatory activity of an aqueous extract of larrea divaricata cav. and digestive and hematological toxicity; Society of Pharmaceutical Sciences & Research; International Journal of Pharmaceutical Sciences and Research; 6; 8; 8-2015; 1000-1010
dc.identifier2320-5148
dc.identifierhttp://hdl.handle.net/11336/18394
dc.identifier0975-8232
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1870795
dc.description.abstractLarrea divaricata Cav. commonly known as “jarilla hembra” is used in folklore medicine as anti-inflammatory. There was no scientific evidence justifying the medicinal use of the aqueous extract for inflammation diseases. Nowadays, there are two principal types of anti-inflammatory drugs: Steroidal anti-inflammatory drugs (corticosteroids) and non-steroidal anti-inflammatory drugs (NSAIDs), which exert gastrointestinal ulceration and bleeding. In this work the preventive anti-inflammatory activity of L. divaricata aqueous extract (AE) in C3H/He mice was determined by carrageenan- induced inflammation and ear edema tests, also its toxicity on gastric tissues and on blood cells was studied. The chromatographic profile showed: nordihydroguaiaretic acid (NDGA) as majority compound. AE exerted anti-inflammatory action without inducing gastric or blood cell toxicities. Also, it could modulate anti-inflammatory and pro-inflammatory cytokines. NDGA was not the compound responsible of the anti-inflammatory action. This work rescues the potentiality of AE as a gastric and blood cells innocuous anti-inflammatory agent and confirms its ethno- pharmacological uses.
dc.languageeng
dc.publisherSociety of Pharmaceutical Sciences & Research
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://ijpsr.com/bft-article/preventive-anti-inflammatory-activity-of-an-aqueous-extract-of-larrea-divaricata-cav-and-digestive-and-hematological-toxicity/?view=fulltext
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.13040/IJPSR.0975-8232.6(8).3215-23
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLarrea divaricata
dc.subjectAnti-inflammatory activity
dc.subjectNordihydroguaiaretic acid
dc.subjectAqueous extract
dc.titlePreventive anti-inflammatory activity of an aqueous extract of larrea divaricata cav. and digestive and hematological toxicity
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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